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dc.contributor.authorGomes, Nelson G. M ( Orcid Icon 0000-0002-8727-9678 )
dc.contributor.authorDasari, Ramesh ( )
dc.contributor.authorChandra, Sunena ( )
dc.contributor.authorKiss, Robert ( )
dc.contributor.authorKornienko, Alexander ( )
dc.date.accessioned2020-05-26T15:49:50Z
dc.date.available2020-05-26T15:49:50Z
dc.date.issued2016-05
dc.identifier.citationGomes, N. G. M., Dasari, R., Chandra, S., Kiss, R., & Kornienko, A. (2016). Marine invertebrate metabolites with anticancer activities: Solutions to the "supply problem." Marine Drugs, 14(5), 98.en_US
dc.identifier.issn1660-3397
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/10311
dc.description.abstractMarine invertebrates provide a rich source of metabolites with anticancer activities and several marine-derived agents have been approved for the treatment of cancer. However, the limited supply of promising anticancer metabolites from their natural sources is a major hurdle to their preclinical and clinical development. Thus, the lack of a sustainable large-scale supply has been an important challenge facing chemists and biologists involved in marine-based drug discovery. In the current review we describe the main strategies aimed to overcome the supply problem. These include: marine invertebrate aquaculture, invertebrate and symbiont cell culture, culture-independent strategies, total chemical synthesis, semi-synthesis, and a number of hybrid strategies. We provide examples illustrating the application of these strategies for the supply of marine invertebrate-derived anticancer agents. Finally, we encourage the scientific community to develop scalable methods to obtain selected metabolites, which in the authors’ opinion should be pursued due to their most promising anticancer activities.en_US
dc.formatText
dc.format.extent39 pages
dc.format.medium1 file (.pdf)
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Instituteen_US
dc.sourceMarine Drugs, 2016, Vol. 14, No. 5, Article 98.
dc.subjectEribulinen_US
dc.subjectTrabectedinen_US
dc.subjectMycalamide Aen_US
dc.subjectSpongistatin 1en_US
dc.subjectStelletin Aen_US
dc.subjectMonanchocidin Aen_US
dc.subjectPhenylmethylene hydantoinen_US
dc.subjectFrondoside Aen_US
dc.subjectDiscodermolideen_US
dc.titleMarine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem"en_US
txstate.documenttypeArticle
dc.rights.holder© 2016 by the authors; licensee MDPI, Basel, Switzerland.
dc.identifier.doihttps://doi.org/10.3390/md14050098
dc.rights.licenseThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
txstate.departmentChemistry and Biochemistry


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