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dc.contributor.authorRohde, Rodney E. ( Orcid Icon 0000-0001-7473-4531 )
dc.date.accessioned2020-12-02T14:35:39Z
dc.date.available2020-12-02T14:35:39Z
dc.date.issued2020-11-16
dc.identifier.citationRohde, R. (2020). What monoclonal antibodies are - and why we need them as well as a vaccine. The Conversation.en
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/13028
dc.description.abstract

When President Trump was diagnosed with COVID-19, one of the cutting-edge experimental therapies he received was a mixture of monoclonal antibodies. But now a vaccine may soon be available. So are other therapies necessary or valuable? And what exactly is a monoclonal antibody?

Over the past few months, the public has learned about many treatments being used to combat COVID-19. An antiviral like remdesivir inhibits the virus from replicating in human cells. Convalescent plasma from the blood of donors who have recovered from COVID-19 may contain antibodies that suppress the virus and inflammation. Steroids like dexamethasone may modify and reduce the dangerous inflammatory damage to the lungs, thereby slowing respiratory failure.

The FDA issued emergency use authorization for Eli Lilly’s monoclonal antibody, called bamlanivimab, and Regeneron is waiting for FDA’s green light for its antibody treatment. Monoclonal antibodies are particularly promising in therapy because they can neutralize the SARS-CoV-2 virus, which causes COVID-19, and block its ability to infect a cell. This might be a lifesaving intervention in people who are unable to mount a strong natural immune response to the virus – those over 65 or with existing conditions that make them more vulnerable.

I’ve worked in public health and medical laboratories for decades, specializing in the study of viruses and other microbes. Even when a vaccine for COVID-19 becomes available, I see a role for monoclonal antibody therapy in getting the pandemic under control.

en
dc.formatText
dc.format.extent4 pages
dc.format.medium1 file (.pdf)
dc.language.isoenen
dc.publisherThe Conversation US, Inc.en
dc.sourceThe Conversation, 2020.
dc.source.urihttps://theconversation.com/what-monoclonal-antibodies-are-and-why-we-need-them-as-well-as-a-vaccine-149356
dc.subjectPandemicen
dc.subjectSteroidsen
dc.subjectVirusesen
dc.subjectMonoclonal antibodiesen
dc.subjectCOVID-19en
dc.subjectSARS-CoV-2en
dc.subjectRemdesiviren
dc.subjectConvalescent plasmaen
dc.subjectAntibodyen
dc.subjectDexamethasoneen
dc.titleWhat monoclonal antibodies are - and why we need them as well as a vaccineen
dc.typepublishedVersion
txstate.documenttypeArticle
dc.rights.licenseCreative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
dc.description.departmentClinical Laboratory Science


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