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dc.contributor.authorLu, Yuan ( )
dc.contributor.authorStarkey, Nicholas ( )
dc.contributor.authorLei, Wei ( )
dc.contributor.authorLi, Jilong ( )
dc.contributor.authorCheng, Jianlin ( Orcid Icon 0000-0003-0305-2853 )
dc.contributor.authorFolk, William R. ( Orcid Icon 0000-0003-2216-3233 )
dc.contributor.authorLubahn, Dennis ( Orcid Icon 0000-0002-6049-0350 )
dc.date.accessioned2021-08-09T21:29:20Z
dc.date.available2021-08-09T21:29:20Z
dc.date.issued2015-12-28
dc.identifier.citationLu, Y., Starkey, N., Lei, W., Li, J., Cheng, J., Folk, W. R., & Lubahn, D. B. (2015). Inhibition of hedgehog-signaling driven genes in prostate cancer cells by Sutherlandia frutescens extract. PLoS One, 10(12), e0145507.en_US
dc.identifier.issn1932-6203
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/14260
dc.description.abstractSutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog (Hh)-signaling in prostate cancer cells and used RNA-Seq transcription profiling to profile gene expression in TRAMPC2 murine prostate cancer cells with or without Sutherlandia extracts. We found 50% of Hh-responsive genes can be repressed by Sutherlandia ethanol extract, including the canonical Hh-responsive genes Gli1 and Ptch1 as well as newly distinguished Hh-responsive genes Hsd11b1 and Penk.en_US
dc.formatText
dc.format.extent9 pages
dc.format.medium1 file (.pdf)
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.sourcePLoS One, 2015, Vol. 10, No. 12, Article e0145507.
dc.subjectProstate canceren_US
dc.subjectGene expressionen_US
dc.subjectCancer treatmenten_US
dc.subjectColorectal canceren_US
dc.subjectSmall cell lung canceren_US
dc.subjectGene ontologiesen_US
dc.subjectEthanolen_US
dc.subjectProstate glanden_US
dc.titleInhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extracten_US
dc.typepublishedVersion
txstate.documenttypeArticle
dc.rights.holder© 2015 Lu et al.
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0145507
dc.rights.licenseCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
dc.description.departmentChemistry and Biochemistry


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