Aptamer Functionalized Electroactive Polymers for Detection of Biomolecules
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3,4-Propylenedioxythiophene (ProDOT) based monomers were synthesized and polymerized via electrochemical polymerization. The electrochemical properties of the resulting polymer films were studied in organic and aqueous solutions using cyclic voltammetry (CV). The polymer films were then functionalized with an adenosine-specific aptamer via click chemistry. Aptamer functionalization was confirmed by fluorescence microscope imaging and by CV. Aptamer functionalized polymer films were used to electrochemically detect adenosine at different concentrations to evaluate the analytical sensing ability of the fabricated biosensor.