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dc.contributor.authorAlcoforado, Luciana ( )
dc.contributor.authorPaiva, Dulciane Nunes ( )
dc.contributor.authorAri, Arzu ( Orcid Icon 0000-0002-3126-8144 )
dc.contributor.authorde Melo Barcelar, Jacqueline ( )
dc.contributor.authorBrandao, Simone Cristina Soares ( )
dc.contributor.authorFink, James B. ( Orcid Icon 0000-0001-6527-2363 )
dc.contributor.authorDornelas de Andrade, Armele ( Orcid Icon 0000-0001-9430-4395 )
dc.date.accessioned2022-11-22T18:59:25Z
dc.date.available2022-11-22T18:59:25Z
dc.date.issued2022-03-04
dc.identifier.citationAlcoforado, L., Paiva, D. N., Ari, A., de Melo Barcelar, J., Brandão, S. C. S., Fink, J. B., & Dornelas de Andrade, A. (2022). Does valved holding chamber improve aerosol lung deposition with a jet nebulizer? A randomized crossover study. Pharmaceutics, 14(3), 566.en_US
dc.identifier.issn1999-4923
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/16335
dc.description.abstractUsing valved holding chambers (VHC) during aerosol therapy has been reported to improve the inhaled dose with various aerosol devices, including vibrating mesh nebulizers. The aim of this study was to quantify the pulmonary deposition of a jet nebulizer (JN) with and without a VHC, and a mesh nebulizer (MN) with a VHC in a randomized cross-over trial with seven healthy consenting adults. Our hypothesis was that the use of a VHC would improve deposition with the JN. Diethylnitriaminopentacetic acid with technetium (DTPA-Tc99m), with the activity of 1 mC with 0.9% saline solution was nebulized. The radiolabeled aerosol was detected by 2D planar scintigraphy after administration. The pulmonary deposition was greater with a JN with a VHC (4.5%) than a JN alone (3.2%; p = 0.005. However, an MN with a VHC (30.0%) was six-fold greater than a JN or JN with a VHC (p < 0.001). The extrapulmonary deposition was higher in the JN group without a VHC than in the other two modalities (p < 0.001). Deposition in the device was greater with a JN + VHC than an MN+/VHC (p < 0.001). Lower residual drug at the end of the dose was detected with an MN than either JN configuration. The exhaled dose was greater with a JN alone than either an MN or JN with VHC (p < 0.001). In conclusion, the addition of the VHC did not substantially improve the efficiency of aerosol lung deposition over a JN alone.en_US
dc.formatText
dc.format.extent9 pages
dc.format.medium1 file (.pdf)
dc.language.isoenen_US
dc.publisherMultidisciplinary Digital Publishing Instituteen_US
dc.sourcePharmaceutics, 2022, Vol. 14, No. 03, Article 566, pp. 1-9.
dc.subjectVibrating mesh nebulizeren_US
dc.subjectJet nebulizeren_US
dc.subjectScintigraphyen_US
dc.subjectSpaceren_US
dc.subjectValved holding chamberen_US
dc.subjectAerosol deliveryen_US
dc.titleDoes Valved Holding Chamber Improve Aerosol Lung Deposition with a Jet Nebulizer? A Randomized Crossover Studyen_US
dc.typepublishedVersion
txstate.documenttypeArticle
dc.identifier.doihttps://doi.org/10.3390/pharmaceutics14030566
dc.rights.licenseCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
dc.description.departmentRespiratory Care


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