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  • Irreversible Protein Labeling by Paal-Knorr Conjugation 

    Dasari, Ramesh; La Clair, James; Kornienko, Alexander (Wiley, 2017-09)
    The application of new chemical reactions in a biological context has advanced bioconjugation methods for both fundamental research and commercial arenas. Recent adaptations of reactions such as Huisgen 1,3-dipolar or ...
  • Biomimetic Nanocoatings with Exceptional Mechanical, Barrier, and Flame-retardant Properties from Large-scale One-step Coassembly 

    Ding, Fuchuan; Liu, Jingjing; Zeng, Songshan; Xia, Yan; Wells, Kacie M.; Nieh, Mu-Ping; Sun, Luyi (American Association for the Advancement of Science, 2017-07)
    Large-scale biomimetic organic/inorganic hybrid nanocoatings with a nacre-like microstructure were prepared via a facile coassembly process. Different from conventional polymer nanocomposites, these nanocoatings contain a ...
  • Ozonated Autohemotherapy Modulates the Serum Levels of Inflammatory Cytokines in Gouty Patients 

    Li, Lian-Yun; Ma, Ruo-Lan; Du, Liqin; Wu, An-Shi (Dove Medical Press, 2017-08)

    Objectives: Ozonated autohemotherapy (O3-AHT) has been used to effectively treat gout, but the underlying therapeutic mechanisms remain unknown. In this study, as an initial effort to understand the therapeutic ...

  • Covalent Modification of Biological Targets with Natural Products through Paal-Knorr pyrrole Formation 

    Kornienko, Alexander; La Clair, James (Royal Society of Chemistry, 2017-08)
    Natural products and endogenous metabolites engage specific targets within tissues and cells through complex mechanisms. This review examines the extent to which natural systems have adopted the Paal-Knorr reaction to ...
  • Chromatin-bound cGAS is an Inhibitor of DNA Repair and Hence Accelerates Genome Destabilization and Cell Death 

    Jiang, Hui; Xue, Xiaoyu; Panda, Swarupa; Kawale, Ajinkya; Hooy, Richard M.; Liang, Fengshan; Sohn, Jungsan; Sung, Patrick; Gekara, Nelson O. (EMBO Press, 2019)
    DNA repair via homologous recombination (HR) is indispensable for genome integrity and cell survival but if unrestrained can result in undesired chromosomal rearrangements. The regulatory mechanisms of HR are not fully ...
  • The Novel Evolution of the Sperm Whale Genome 

    Warren, Wesley C.; Kuderna, Lukas; Alexander, Alana; Catchen, Julian; Perez-Silva, Jose G.; Lopez-Otin, Carlos; Quesada, Victor; Minx, Patrick; Tomlinson, Chad; Montague, Michael J.; Farias, Fabiana; Walter, Ronald B.; Marques-Bonet, Tomas; Glenn, Travis C.; Kieran, Troy J.; Wise, Sandra S.; Wise, John Pierce, Jr.; Waterhouse, Robert M.; Wise, John Pierce, Sr. (Oxford University Press, 2017-09)
    The sperm whale, made famous by Moby Dick, is one of the most fascinating of all ocean-dwelling species given their unique life history, novel physiological adaptations to hunting squid at extreme ocean depths, and their ...
  • Exposure to 4100K Fluorescent Light Elicits Sex Specific Transcriptional Responses in Xiphophorus maculatus Skin 

    Boswell, William T.; Boswell, Mikki; Walter, Dylan J.; Navarro, Kaela L.; Chang, Jordan; Lu, Yuan; Savage, Markita G.; Shen, Jianjun; Walter, Ronald B. (Elsevier, 2018-06)
    It has been reported that exposure to artificial light may affect oxygen intake, heart rate, absorption of vitamins and minerals, and behavioral responses in humans. We have reported specific gene expression responses in ...
  • Fluorescent Light Exposure Incites Acute and Prolonged Immune Responses in Zebrafish (Danio rerio) Skin 

    Gonzalez, Trevor J.; Lu, Yuan; Boswell, Mikki; Boswell, William T.; Medrano, Geraldo; Walter, Sean M.; Ellis, Samuel; Savage, Markita G.; Varga, Zoltan M.; Lawrence, Christian; Sanders, George; Walter, Ronald B. (Elsevier, 2018-09)
    Artificial light produces an emission spectrum that is considerably different than the solar spectrum. Artificial light has been shown to affect various behavior and physiological processes in vertebrates. However, there ...
  • The Transcriptional Response of Skin to Fluorescent Light Exposure in Viviparous (Xiphophorus) and Oviparous (Danio, Oryzias) Fishes 

    Boswell, Mikki; Boswell, William T.; Lu, Yuan; Savage, Markita G.; Mazurek, Zachary; Chang, Jordan; Muster, Jeanot; Walter, Ronald B. (Elsevier, 2018-06)
    Differences in light sources are common in animal facilities and potentially can impact experimental results. Here, the potential impact of lighting differences on skin transcriptomes has been tested in three aquatic animal ...
  • Biomedical Application of Electroactive Polymers in Electrochemical Sensors: A Review 

    Runsewe, Damilola; Betancourt, Tania; Irvin, Jennifer A. (Multidisciplinary Digital Publishing Initiative, 2019-08)
    Conducting polymers are of interest due to their unique behavior on exposure to electric fields, which has led to their use in flexible electronics, sensors, and biomaterials. The unique electroactive properties of conducting ...
  • Expression Signatures of Early-stage and Advanced Medaka Melanomas 

    Klotz, Barbara; Kneitz, Susanne; Regensburger, Martina; Hahn, Lena; Dannemann, Michael; Kelso, Janet; Nickel, Birgit; Lu, Yuan; Boswell, William T.; Postlethwait, John; Warren, Wesley C.; Kunz, Manfred; Walter, Ronald B.; Schartl, Manfred (Elsevier, 2018-06)
    Melanoma is one of the most aggressive tumors with a very low survival rate once metastasized. The incidence of newly detected cases increases every year suggesting the necessity of development and application of innovative ...
  • Characterization of Basal Gene Expression Trends over a Diurnal Cycle in Xiphophorus maculatus Skin, Brain and Liver 

    Lu, Yuan; Reyes, Jose; Walter, Sean M.; Gonzalez, Trevor J.; Medrano, Geraldo; Boswell, Mikki; Boswell, William T.; Savage, Markita G.; Walter, Ronald B. (Elsevier, 2018-06)
    Evolutionarily conserved diurnal circadian mechanisms maintain oscillating patterns of gene expression based on the day-night cycle. Xiphophorus fish have been used to evaluate transcriptional responses after exposure to ...
  • Factors Affecting the Association of Single- and Double-Stranded RNAs with Montmorillonite Nanoclays 

    Gujjari, Archana; Rodriguez, Blanca V.; Pescador, Jorge; Maeder, Corina; Beall, Gary W.; Lewis, L. Kevin (Elsevier, 2018-04)
    Montmorillonite (MMT) nanoclays exist as single and stacked sheet-like structures with large surface areas that can form stable associations with many naturally occurring biomolecules, including nucleic acids. They have ...
  • A Three Year Study of Metal Levels in Skin Biopsies of Whales in the Gulf of Mexico after the Deepwater Horizon Oil Crisis 

    Wise, John Pierce, Jr.; Wise, James T. F.; Wise, Catherine F.; Wise, Sandra S.; Gianios, Christy, Jr.; Xie, Hong; Walter, Ronald B.; Boswell, Mikki; Zhu, Cairong; Zheng, Tongzhang; Perkins, Christopher; Wise, John Pierce, Sr. (Elsevier, 2018-02)
    In response to the explosion of the Deepwater Horizon and the massive release of oil that followed, we conducted three annual research voyages to investigate how the oil spill would impact the marine offshore environment. ...
  • Novel Topologically Complex Scaffold Derived from Alkaloid Haemanthamine 

    Govindaraju, Karthik; Masi, Marco; Colin, Margaux; Mathieu, Veronique; Evidente, Antonio; Hudnall, Todd W.; Kornienko, Alexander (Multidisciplinary Digital Publishing Institute (MDPI), 2018-01)
    The generation of natural product-like compound collections has become an important area of research due to low hit rates found with synthetic high-throughput libraries. One method of generating compounds occupying the ...
  • Synthetic Analogues of the Montanine-type Alkaloids with Activity Against Apoptosis-resistant Cancer Cells 

    Govindaraju, Karthik; Ingels, Aude; Hasan, Md Nabiul; Sun, Dandan; Mathieu, Veronique; Masi, Marco; Evidente, Antonio; Kornienko, Alexander (Elsevier, 2018-02)
    In a search of small molecules active against apoptosis-resistant cancer cells, a skeletal rearrangement of alkaloid haemanthamine was utilized to generate a series of compounds possessing the alkaloid montanine ring system. ...
  • miR-195 Targets Cyclin D3 and Survivin to Modulate the Tumorigenesis of Non-small Cell Lung Cancer 

    Yu, Xiaojie; Zhang, Yiqiang; Cavazos, David; Ma, Xiuye; Zhao, Zhenze; Du, Liqin; Pertsemlidis, Alexander (Nature Publishing Group, 2018-02)
    miR-195 has recently been reported to function as a tumor suppressor in various cancers, including non-small cell lung cancer (NSCLC). However, the mechanisms by which miR-195 represses the tumorigenesis of NSCLC cells are ...
  • Sequence Reversal Prevents Chain Collapse and Yields Heat-Sensitive Intrinsic Disorder 

    English, Lance R.; Tischer, Alexander; Demeler, Aysha K.; Demeler, Borries; Whitten, Steven T. (Biophysical Society (Elsevier), 2018-07)
    Sequence patterns of charge, hydrophobicity, hydrogen bonding, and other amino acid physicochemical properties contribute to mechanisms of protein folding, but how sequence composition and patterns influence the conformational ...
  • Clonal Polymorphism and High Heterozygosity in the Celibate Genome of the Amazon Molly 

    Warren, Wesley C.; Garcia-Perez, Raquel; Xu, Sen; Lampert, Kathrin P.; Chalopin, Domitille; Stock, Matthias; Loewe, Laurence; Lu, Yuan; Kuderna, Lukas; Minx, Patrick; Montague, Michael J.; Tomlinson, Chad; Hillier, LaDeana W.; Murphy, Daniel N.; Wang, John; Wang, Zhongwei; Garcia, Constantino Macias; Thomas, Gregg W. C.; Volff, Jean-Nicolas; Farias, Fabiana; Aken, Bronwen; Walter, Ronald B.; Pruitt, Kim D.; Marques-Bonet, Tomas; Hahn, Matthew W.; Kneitz, Susanne; Lynch, Michael; Schartl, Manfred (Nature Publishing Group, 2018-04)
    The extreme rarity of asexual vertebrates in nature is generally explained by genomic decay due to absence of meiotic recombination, thus leading to extinction of such lineages. We explore features of a vertebrate asexual ...
  • Polygodial Analog induces Apoptosis in LNCaP Prostate Cancer Cells 

    Dasari, Subramanyam; Samy, Angela Lincy Prem Antony; Narvekar, Parnal; Dontaraju, Venkata Satish; Dasari, Ramesh; Kornienko, Alexander; Munirathinam, Gnanasekar (Elsevier, 2018-06)
    Prostate cancer (PCa) is the second leading cause of death in American men. The chemotherapeutic treatment strategies are generally not effective and can lead to side effects. Hence, there is an urgent need to identify ...

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