RSS 1.0Theses and Dissertations-Chemistry and Biochemistry
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Characterizing the Activity of Three Novel Differentiation-Inducing Compounds in Neuroblastoma Cells
(2020-05)Neuroblastoma is the most common extracranial tumor in children. It makes up 8% of all childhood cancers and is the cause of 15% of all childhood cancer-related deaths. Neuroblastoma arises from neural crest precursor ...
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Novel Neuroblastoma Differentiating Agents
(2020-05)Neuroblastoma (NB) is the 3rd most lethal pediatric cancer. In high-risk patients, the 5-year survival rate is 40-50% after treatment. The differentiation therapy with retinoic acid (RA) is at the forefront of approaches ...
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The synthesis and characterization of new, fluoride-containing polyacrylates derived from 2-hydroxyhexafluoroisopropylbenzene
(1999-05)Acrylate polymers are known for their clarity, lack of color and stability upon aging under severe conditions. These characteristics, along with the versatility and ability to tailor these polymers relatively easily ...
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Molecular characterization and relative expression of the Xiphophorus maculatus apurinic/apyrimidinic endonuclease gene
(2003-12)No abstract prepared. -
Synthesis of tin containing calix[4]arenes and their anion binding capabilities
(1999-05)Extensive research has been done on the ability of calixarenes to complex cations and neutral species. The electron-rich molecular cavity and lower rim consisting of a cyclic array of oxygen donors makes the structure ...
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Aptamer Functionalized Electroactive Polymers for Detection of Biomolecules
(2020-12)3,4-Propylenedioxythiophene (ProDOT) based monomers were synthesized and polymerized via electrochemical polymerization. The electrochemical properties of the resulting polymer films were studied in organic and aqueous ... -
c-MYC G-Quadruplex DNA Structures: Characterization and Photocleavage
(2018-08)No abstract prepared. -
In-Silico Guided Synthesis and Characterization of Novel Electrophilic Carbenes
(2018-08)The synthesis and electronic characterization of two new electrophilic carbenes is described. The synthesized carbenes were selected based on computational studies investigating the HOMO and LUMO energies of various new ...
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Synthesis and Characterization of Pyridinium Derivatives for Application in Non-Aqueous Redox Flow Batteries
(2018-08)As renewable energy sources are further explored for integration into the electric grid on which we all rely, the question of how to meet energy storage demand in an equally “green” way arises. One potential solution ...
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Nanostructured Titanium Oxynitride-Supported Iridium Oxide Oxygen Evolution Electrocatalysts for Water Splitting
(2018-08)Proton exchange membrane water electrolyzers (PEM-WE) have garnered much interest lately because of their ability to produce storable hydrogen from the simple inputs of water and electricity. Two half reactions drive the ... -
Mechanical Properties of Polymer-Clay Nanocomposite Thin Films
(2021-12)Clay-containing polymer nanocomposites applied as thin films have been found to have superior mechanical properties over isolated clay or polymer treatments. The majority of early studies of polymer-clay nanocomposites ...
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Synthesis and cation binding properties of bis-bridged calix[6]arenes
(1999-12)Calixarenes have been studied and utilized for their molecular recognition properties. A total of four bis-bridged calix[6]arenes have been synthesized and their metal binding properties and structural conformations were ... -
Electrochemistry of electroless plating on optical fiber for sensors and vanadium sulfide cathodes for batteries
(2019-08)The first part of this thesis proposes methods to monitor internal corrosion before catastrophic events occur. Internal corrosion accounts for about 60% of all natural gas transmission and gathering pipeline incidents ...
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Investigating the Novel Oncogenic Function of SAPCD2 in Pediatric Neuroblastoma
(2021-08)Pediatric neuroblastoma is the most common extra-cranial solid malignancy in infants and children. It is an aggressive neuroendocrine cancer that circumvents the normal differentiation process of sympathetic neuronal ... -
Novel Ambient Ionization Sampling Methodologies With Mass Spectrometry
(2020-05)Expanding on the current paradigm of ambient ionization, herein is reported the use of a metal surface for metal spray ionization and the use of online derivatization to separate isomass compounds. A metal surface has ...
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Mechanisms of Human LARP6 Nuclear Export
(2019-05)The La Related Protein 6 (LARP6) regulates the expression of type I collagen synthesis by binding to the encoding mRNA. However, the molecular mechanism of ligand binding and cellular localization is not fully understood. ... -
Using Heat Effects on Coil Hydrodynamic Size to Reveal the Nature and Energetics of Denatured State Conformational Bias
(2019-12)Conformational equilibria in the protein denatured state have key roles regulating folding, stability, and function. The extent of conformational bias in the denatured state under folding conditions, however, has thus far ... -
Purification and partial characterization of pokeweed antiviral protein immunoreactive species
(2001-05)No abstract prepared. -
Investigation of the mechanism of nucleophilic attack on the [trans-BH] anion
(2006-08)The substitution chemistry of the [trans-B20H18]2- anion was first investigated by Hawthorne and coworkers. The product formed from the reaction of the [trans-B20H18]2- anion with the hydroxide ion is an ...
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A survey of dimeric mu-bridged compounds and determination of unit cell dimensions of several Pt-complexes
(1971-05)The objective of the problem was to survey recent literature for all mu-bridged compounds and to determine the unit cell dimensions of several platinum complexes.
The literature survey was done using ...
