Theses and Dissertations-Chemistry and Biochemistry

Sequence-Based Properties that Identify Intrinsically Disordered Phase-Separating Protein Regions

Ibrahim, Ayyam (2022-08)

We aimed to investigate the molecular mechanisms that drive liquid-liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs). This phenomenon is critical in many cellular processes (including RNA ...

Deposition of Electroactive Polymers onto Polymer Nanofibers for Nerve Regeneration

Santiago, Marvin D. (2022-08)

Although peripheral nerves can regenerate after an injury through the Wallerian degeneration process, the degree of regeneration is often not efficient enough to achieve full return of functionality. To overcome the ...

Impact of DNA End Structure and Cellular Growth Phase on DNA Repair by Nonhomologous End-Joining (NHEJ) in Saccharomyces cerevisiae

Fitzgerald, O'Taveon R. (2020-08)

No abstract prepared.

Effect of Thermal Treatment on Structure and Properties of Niobium Oxide Aerogels as Electrolyzer Catalyst Supports

Albiter, Luis A. (2020-08)

Oxygen evolution reaction (OER) catalyst limitations including cost, activity, and stability remain bottlenecks to the wide scale adoption of proton exchange membrane (PEM) water electrolyzers used to split water into ...

Synthesis of CAPA and its Analogues for Analysis of Anti-Cancer Activity, and Computational Docking of CAPE, CAPA and Analogues with the DRS of p38α

Jemal, Mauricio A. (2020-08)

A Caffeic acid phenethyl amide (CAPA) is the amide derivative of caffeic acid phenethyl ester (CAPE), a bioactive extract from propolis. CAPE has been extensively studied and shown to be cytotoxic in many cancer cell lines. ...

Inhibition of mitogen-activated protein kinase p38α by rooperol and analogues

Davis, Chelsea S. (2020-08)

Cancer therapeutic drugs have evolved over time in correlation with the understanding of the biological mechanisms which they affect. Many anti-cancer leads have been found in natural sources. The African potato, ...

Metal Substitution within Nanostructured Nickel Hydroxides for Aqueous Rechargeable Nickel–Zinc Batteries

Kimmel, Samuel W. (2020-08)

Developing batteries with high gravimetric and volumetric energy density, improved safety, and lower cost is a critical need for a wide range of applications including electric vehicles, portable electronic devices, and ...

Effects of Magnesium Reduction on the Structure and Electrical Properties of Tantalum Oxide Aerogels

Aguirre, Lupita S. (2020-08)

Electrocatalyst supports that have resistance to corrosion, high surface area, high porosity, and adequate electronic conductivity are needed to improve the durability of proton-exchange membrane fuel cells (PEMFC) utilized ...

The N-terminal region of the Arabidopsis thaliana LaRP6C protein contributes to structural stability

Roberts, Julia E. (2020-05)

The La-related proteins (LaRPs) are a superfamily of RNA-binding proteins that are distinguished by a core RNA binding domain called the “La Module”. This family is highly conserved across eukaryotes and exerts ...

The Structural and Functional Role of Vertebrate LaRP6 N-Terminal Region

Godinez, Brianna (2020-05)

La-related protein 6 (LaRP6) belongs to a superfamily of evolutionarily related RNA-binding proteins. While other LaRP families have been characterized more thoroughly, LaRP6 is still poorly understood. The majority of the ...

Doublet Emitters Derived from Stable Carbenes for Potential OLED Applications

Harmon, Gabrielle (2020-05)

Organic light emitting diodes (OLEDs) typically exhibit low quantum efficiencies (~19%) due to quantum mechanical limitations and spin statistics. In traditional OLEDs, the emitting excitons are either singlet (25%) or ...

Characterizing the Activity of Three Novel Differentiation-Inducing Compounds in Neuroblastoma Cells

Oviedo, Alejandro (2020-05)

Neuroblastoma is the most common extracranial tumor in children. It makes up 8% of all childhood cancers and is the cause of 15% of all childhood cancer-related deaths. Neuroblastoma arises from neural crest precursor ...

Novel Neuroblastoma Differentiating Agents

Laguera, Breana (2020-05)

Neuroblastoma (NB) is the 3rd most lethal pediatric cancer. In high-risk patients, the 5-year survival rate is 40-50% after treatment. The differentiation therapy with retinoic acid (RA) is at the forefront of approaches ...

The synthesis and characterization of new, fluoride-containing polyacrylates derived from 2-hydroxyhexafluoroisopropylbenzene

Oba, Jean Baptiste (1999-05)

Acrylate polymers are known for their clarity, lack of color and stability upon aging under severe conditions. These characteristics, along with the versatility and ability to tailor these polymers relatively easily ...