RSS 1.0Theses and Dissertations-Chemistry and Biochemistry
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p38-alpha Inhibition by Rooperol: Docking and Kinase Assay Studies
(2021-08)p38α is a protein kinase with a high importance in cell metabolism due to its role in inflammation, apoptosis, differentiation, and cell cycle regulation. It is activated by a cascade of reactions that starts with cytokines, ... -
Nanomedicine-mediated Reprogramming of Tumor Immunogenicity
(2021-08)Cancer is the second leading cause of death in the United States and has a major impact on our society. Melanoma is listed as one of the top leading cancers in men and women and was expected to account for 6,850 cancer ... -
Polymer Properties that Predict Protein Structure Class from the Primary Sequence
(2022-12)Within cells, membrane-free compartments form spontaneously and reversibly in a process referred to as “phase separation”. By forming specific compartments and microenvironments, these membraneless organelles, for example, ... -
Synthesis of Mixed Bis-Azobenzene for Photosurfactant Studies
(2022-12)Photosurfactants are an emerging field of research due to their capacity for self-assembly and micellization properties. Azobenzene derivatives are of interest because not only do they have photoisomerization potential but ... -
Jeffamine-epoxy toughened unsaturated polyester, interpenetrating polymer network (IPN)
(1999-12)A series (15:85%) translucent intact IPNs made of a reactive rubber (Jeffamine™), a commercially available epoxy and unsaturated polyester were prepared. All IPNs showed increased toughness with incorporation of the Jeffoxy ... -
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Assay development and purification of 2-(2'-hydroxyphenyl) benzenesulfinate (HPBS) desulfinase
(2000-05)All fossil fuels are composed primarily of carbon and hydrogen, but also contain sulfur and nitrogen. The presence of sulfur contributes to the corrosion of pipelines, production and refining equipment. When fossil fuels ...
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Evaluation of solid phase extraction (SPE) for the analysis of isocyanates in spray-painting operations
(1998-08)Polyisocyanates of 1,6-hexamethylene diisocyanate (HDI) were initially introduced as an alternative to HDI monomer for use in polyurethane paint. The chemical class of isocyanates is utilized in polyurethane paints as ...
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Sequence-Based Properties that Identify Intrinsically Disordered Phase-Separating Protein Regions
(2022-08)We aimed to investigate the molecular mechanisms that drive liquid-liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs). This phenomenon is critical in many cellular processes (including RNA ...
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Deposition of Electroactive Polymers onto Polymer Nanofibers for Nerve Regeneration
(2022-08)Although peripheral nerves can regenerate after an injury through the Wallerian degeneration process, the degree of regeneration is often not efficient enough to achieve full return of functionality. To overcome the ...
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Impact of DNA End Structure and Cellular Growth Phase on DNA Repair by Nonhomologous End-Joining (NHEJ) in Saccharomyces cerevisiae
(2020-08)No abstract prepared. -
Effect of Thermal Treatment on Structure and Properties of Niobium Oxide Aerogels as Electrolyzer Catalyst Supports
(2020-08)Oxygen evolution reaction (OER) catalyst limitations including cost, activity, and stability remain bottlenecks to the wide scale adoption of proton exchange membrane (PEM) water electrolyzers used to split water into ... -
Synthesis of CAPA and its Analogues for Analysis of Anti-Cancer Activity, and Computational Docking of CAPE, CAPA and Analogues with the DRS of p38α
(2020-08)A Caffeic acid phenethyl amide (CAPA) is the amide derivative of caffeic acid phenethyl ester (CAPE), a bioactive extract from propolis. CAPE has been extensively studied and shown to be cytotoxic in many cancer cell lines. ... -
Inhibition of mitogen-activated protein kinase p38α by rooperol and analogues
(2020-08)Cancer therapeutic drugs have evolved over time in correlation with the understanding of the biological mechanisms which they affect. Many anti-cancer leads have been found in natural sources. The African potato, ...
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Metal Substitution within Nanostructured Nickel Hydroxides for Aqueous Rechargeable Nickel–Zinc Batteries
(2020-08)Developing batteries with high gravimetric and volumetric energy density, improved safety, and lower cost is a critical need for a wide range of applications including electric vehicles, portable electronic devices, and ... -
Effects of Magnesium Reduction on the Structure and Electrical Properties of Tantalum Oxide Aerogels
(2020-08)Electrocatalyst supports that have resistance to corrosion, high surface area, high porosity, and adequate electronic conductivity are needed to improve the durability of proton-exchange membrane fuel cells (PEMFC) utilized ... -
The N-terminal region of the Arabidopsis thaliana LaRP6C protein contributes to structural stability
(2020-05)The La-related proteins (LaRPs) are a superfamily of RNA-binding proteins that are distinguished by a core RNA binding domain called the “La Module”. This family is highly conserved across eukaryotes and exerts ... -
The Structural and Functional Role of Vertebrate LaRP6 N-Terminal Region
(2020-05)La-related protein 6 (LaRP6) belongs to a superfamily of evolutionarily related RNA-binding proteins. While other LaRP families have been characterized more thoroughly, LaRP6 is still poorly understood. The majority of the ... -
Doublet Emitters Derived from Stable Carbenes for Potential OLED Applications
(2020-05)Organic light emitting diodes (OLEDs) typically exhibit low quantum efficiencies (~19%) due to quantum mechanical limitations and spin statistics. In traditional OLEDs, the emitting excitons are either singlet (25%) or ...
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Characterizing the Activity of Three Novel Differentiation-Inducing Compounds in Neuroblastoma Cells
(2020-05)Neuroblastoma is the most common extracranial tumor in children. It makes up 8% of all childhood cancers and is the cause of 15% of all childhood cancer-related deaths. Neuroblastoma arises from neural crest precursor ...
