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dc.contributor.advisorKoke, Joseph R.
dc.contributor.authorStecker, John ( )
dc.date.accessioned2012-08-15T19:26:40Z
dc.date.available2012-08-15T19:26:40Z
dc.date.issued2011-12
dc.identifier.citationStecker, J. (2011). Aptamer interactions and applications in cancer treatment (Unpublished thesis). Texas State University-San Marcos, San Marcos, Texas.
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/4331
dc.description.abstractAptamers, small strands of RNA or DNA, are finding a rapidly expanding repertoire of applications. Aptamers have found numerous diagnostic and therapeutic uses both in vitro and in vivo. Specifically, their application in diagnosis and treatment of multiple cancers has been strongly advanced over the last decade. In this study, two different applications of aptamers are explored for two different cancers. In the murine liver cancer cell line, BNL 1ME A.7R.1 (MEAR), the TLS-11a aptamer is shown to quickly internalize at physiological temperatures. The TLS-11a aptamer is therefore a potential candidate for intracellular toxin delivery as a means of inducing targeted apoptosis of the MEAR cancer cells. In the human breast cancer cell line MCF7, the MUC1-5TR aptamer is shown to successfully initiate the classical complement pathway leading to complement fixation on the target cell via a streptavidin-C1q conjugation. This model provides a way to help the human immune system specifically target and remove cancerous cells.
dc.formatText
dc.format.extent68 pages
dc.format.medium1 file (.pdf)
dc.language.isoen_US
dc.subjectCancer
dc.subjectAptamer
dc.subject.lcshCancer--Treatmenten_US
dc.subject.lcshAmino acidsen_US
dc.subject.lcshNucleic acidsen_US
dc.subject.lcshPolypeptidesen_US
dc.titleAptamer Interactions and Applications in Cancer Treatment
txstate.documenttypeThesis
dc.contributor.committeeMemberGarcía, Dana
dc.contributor.committeeMemberBruno, John G.
thesis.degree.departmentBiology
thesis.degree.disciplineBiology
thesis.degree.grantorTexas State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science
txstate.departmentBiology


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