A Non-enzymatic Continuous Glucose Monitoring System Using Electrochemical Impedance Spectroscopy
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The following research is a feasibility trial for the development of a continuous glucose monitoring system using electrochemical impedance spectroscopy. Three separate experiments are conducted to determine the effects of electrode surface area on sensing efficacy, the effects of glucose concentration on impedimetric response, and a real time measuring trial of glucose sensing at low, medium, and high concentration levels over a period of fixed frequency and voltage excitation. The resultant data from each of the trials is modeled using electrical equivalent circuits and analyzed via Nyquist and Bode configurations to identify relevant data for each experiment. Results indicate that as electrode surface area increases, the impedimetric response decreases and sensitivity is increased. Deviations throughout the entire glucose range are detected as an inverse of the impedance in the cell due to the inverse relationship of glucose concentration and charge transfer resistance. The continuous monitoring of glucose is demonstrated by a rapid device response over two iterations of glucose concentration in ascending order. As concentration increases, resolution of the impedance signature is reduced suggesting the approach of a saturation set point.