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dc.contributor.advisorMcLean, Robert JC
dc.contributor.authorThornhill, Starla
dc.date.accessioned2018-08-13T18:17:52Z
dc.date.available2018-08-13T18:17:52Z
dc.date.issued4/13/2016
dc.date.submittedMay 2016
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/7485
dc.description.abstractBacteria are single celled organisms capable of acting as a single unit by sensing and responding to population density via a phenomenon called quorum signaling. Quorum signaling regulates a variety of phenotypes including biofilm formation and virulence factor production. In the soil bacterium Chromobacterium violaceum the virulence factor violacein results in a deep purple pigmentation and is one such regulated phenotype. Previously, a number of biological and organic molecules have been described as quorum signaling inhibitors, but to date no metal-based inhibitors have been identified. In this study, we show that quorum sensing is inhibited in C. violaceum when in the presence of sub-lethal concentrations of cadmium based salts. Cobalt and nickel salts have also been indicated as inhibitors in other gram negative species. Inhibitory effects of cadmium divalent cations on C. violaceum were shown in biofilm formation, pigmentation and virulence factor production, as well as transcript levels for genes involved in these processes. This study represents the first description of heavy metal based quorum sensing inhibition in C. violaceum.
dc.formatText
dc.format.extent44 pages
dc.format.medium1 file (.pdf)
dc.language.isoen_US
dc.subjectQuorum Signaling
dc.subjectBiofilm
dc.subjectAHL
dc.subjectChromobacterium Violaceum
dc.subjectC. Violaceum
dc.subjectQuorum Sensing
dc.subjectQuorum Sensing Inhibition
dc.subjectCadmium
dc.subjectCobalt
dc.subjectNickel
dc.titleInhibition of quorum signalling and biofilm formation in Chromobacterium violaceum in the presence of cadmium, cobalt and nickel divalent cations
txstate.documenttypeThesis
dc.contributor.committeeMemberVega, Leticia
dc.contributor.committeeMemberKakirde, Kavita
thesis.degree.departmentBiology
thesis.degree.disciplineBiology
thesis.degree.grantorTexas State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science
txstate.departmentBiology


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