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dc.contributor.authorSmallwood, Rachel F.
dc.contributor.authorPrice, Larry R.
dc.contributor.authorCampbell, Jenna L.
dc.contributor.authorGarrett, Amy S.
dc.contributor.authorAtalla, Sebastian W.
dc.contributor.authorMonroe, Todd B.
dc.contributor.authorAytur, Semra A.
dc.contributor.authorPotter, Jennifer S.
dc.contributor.authorRobin, Donald A.
dc.date.accessioned2019-07-30T14:40:13Z
dc.date.available2019-07-30T14:40:13Z
dc.date.issued2019
dc.identifier.citationSmallwood, R. F., Price, L. R., Campbell, J. L., Garrett, A. S., Atalla, S. W., Monroe, T. B., Aytur, S. A., Potter, J. S., & Robin, D. A. (2019). Network Alterations in Comorbid Chronic Pain and Opioid Addiction: An Exploratory Approach. Frontiers in human neuroscience, 13(174).en_US
dc.identifier.issn1662-5161
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/8415
dc.description.abstractThe comorbidity of chronic pain and opioid addiction is a serious problem that has been growing with the practice of prescribing opioids for chronic pain. Neuroimaging research has shown that chronic pain and opioid dependence both affect brain structure and function, but this is the first study to evaluate the neurophysiological alterations in patients with comorbid chronic pain and addiction. Eighteen participants with chronic low back pain and opioid addiction were compared with eighteen age- and sex-matched healthy individuals in a pain-induction fMRI task. Unified structural equation modeling (SEM) with Lagrange multiplier (LM) testing yielded a network model of pain processing for patient and control groups based on 19 a priori defined regions. Tests of differences between groups on specific regression parameters were determined on a path-by-path basis using z-tests corrected for the number of comparisons. Patients with the chronic pain and addiction comorbidity had increased connection strengths; many of these connections were interhemispheric and spanned regions involved in sensory, affective, and cognitive processes. The affected regions included those that are commonly altered in chronic pain or addiction alone, indicating that this comorbidity manifests with neurological symptoms of both disorders. Understanding the neural mechanisms involved in the comorbidity is crucial to finding a comprehensive treatment, rather than treating the symptoms individually.en_US
dc.formatText
dc.format.extent12 pages
dc.format.medium1 file (.pdf)
dc.language.isoen_USen_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.sourceFrontiers in Human Neuroscience, 2019, Vol. 13, No. 174
dc.subjectChronic low back painen_US
dc.subjectOpioid addiction
dc.subjectfMRI
dc.subjectPain induction
dc.subjectUnified structural equation modeling
dc.subjectVector autoregressive modeling
dc.subjectAutomated search strategy
dc.titleNetwork Alterations in Comorbid Chronic Pain and Opioid Addiction: An Exploratory Approachen_US
txstate.documenttypeArticle
dc.identifier.doihttps:doi.org/10.3389/fnhum.2019.00174
txstate.departmentCounseling, Leadership, Adult Education, and School Psychology


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