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dc.contributor.authorReinus, Brandon ( )
dc.contributor.authorKerwin, Sean M. ( )
dc.date.accessioned2019-07-31T17:59:21Z
dc.date.available2019-07-31T17:59:21Z
dc.date.issued2019
dc.identifier.citationReinus, B., & Kerwin, S. M. (2019). Preparation and Utility of N-Alkynyl Azoles in Synthesis. Molecules, 24(3).en_US
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/8434
dc.description.abstractHeteroatom-substituted alkynes have attracted a significant amount of interest in the synthetic community due to the polarized nature of these alkynes and their utility in a wide range of reactions. One specific class of heteroatom-substituted alkynes combines this utility with the presence of an azole moiety. These N-alkynyl azoles have been known for nearly 50 years, but recently there has been a tremendous increase in the number of reports detailing the synthesis and utility of this class of compound. While much of the chemistry of N-alkynyl azoles mirrors that of the more extensively studied N-alkynyl amides (ynamides), there are notable exceptions. In addition, as azoles are extremely common in natural products and pharmaceuticals, these N-alkynyl azoles have high potential for accessing biologically important compounds. In this review, the literature reports of N-alkynyl azole synthesis, reactions, and uses have been assembled. Collectively, these reports demonstrate the growth in this area and the promise of exploiting N-alkynyl azoles in synthesis.en_US
dc.formatText
dc.format.extent56 pages
dc.format.medium1 file (.pdf)
dc.language.isoen_USen_US
dc.publisherMultidisciplinary Digital Publishing Instituteen_US
dc.sourceMolecules, 2019, Vol. 24, No. 3
dc.subjectAlkynesen_US
dc.subjectCarbenes
dc.subjectCyclizations
dc.subjectNatural products
dc.subjectPolymers
dc.titlePreparation and Utility of N-Alkynyl Azoles in Synthesisen_US
txstate.documenttypeArticle
dc.identifier.doihttps://doi.org/10.3390/molecules24030422
txstate.departmentChemistry and Biochemistry


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