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dc.contributor.authorLu, Yuan
dc.contributor.authorWalter, Ronald B.
dc.contributor.authorBoswell, Mikki
dc.contributor.authorBoswell, William T.
dc.contributor.authorKneitz, Susanne
dc.contributor.authorKlotz, Barbara
dc.contributor.authorSavage, Markita G.
dc.contributor.authorSalinas, Raquel
dc.contributor.authorMarks, Rebecca
dc.contributor.authorRegneri, Janine
dc.contributor.authorPostlethwait, John
dc.contributor.authorWarren, Wesley C.
dc.contributor.authorSchartl, Manfred
dc.date.accessioned2019-08-02T14:30:06Z
dc.date.available2019-08-02T14:30:06Z
dc.date.issued2018
dc.identifier.citationLu, Y., Boswell, M., Boswell, W., Kneitz, S., Klotz, B., Savage, M., Salinas, R., Marks, R., Regneri, J., Postlethwait, J., Warren, W. C., Schartl, M., & Walter, R. (2018). Gene expression variation and parental allele inheritance in a Xiphophorus interspecies hybridization model. PLoS Genetics, 14(12), e1007875.en_US
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/8438
dc.description.abstractUnderstanding the genetic mechanisms underlying segregation of phenotypic variation through successive generations is important for understanding physiological changes and disease risk. Tracing the etiology of variation in gene expression enables identification of genetic interactions, and may uncover molecular mechanisms leading to the phenotypic expression of a trait, especially when utilizing model organisms that have well-defined genetic lineages. There are a plethora of studies that describe relationships between gene expression and genotype, however, the idea that global variations in gene expression are also controlled by genotype remains novel. Despite the identification of loci that control gene expression variation, the global understanding of how genome constitution affects trait variability is unknown. To study this question, we utilized Xiphophorus fish of different, but tractable genetic backgrounds (inbred, F1 interspecies hybrids, and backcross hybrid progeny), and measured each individual's gene expression concurrent with the degrees of inter-individual expression variation. We found, (a) F1 interspecies hybrids exhibited less variability than inbred animals, indicting gene expression variation is not affected by the fraction of heterozygous loci within an individual genome, and (b), that mixing genotypes in backcross populations led to higher levels of gene expression variability, supporting the idea that expression variability is caused by heterogeneity of genotypes of cis or trans loci. In conclusion, heterogeneity of genotype, introduced by inheritance of different alleles, accounts for the largest effects on global phenotypical variability.en_US
dc.formatText
dc.format.extent16 pages
dc.format.medium1 file (.pdf)
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.sourcePLOS Genetics, 2018, Vol. 14, No. 12, e1007875
dc.subjectGene expression
dc.subjectInbreeding
dc.subjectXiphophorus
dc.subjectGene regulation
dc.subjectAlleles
dc.subjectVariant genotypes
dc.subjectGenetic loci
dc.subjectMelanomas
dc.titleGene Expression Variation and Parental Allele Inheritance in a Xiphophorus Interspecies Hybridization Modelen_US
txstate.documenttypeArticle
dc.identifier.doihttps://doi.org/10.1371/journal.pgen.1007875
dc.rights.licenseThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
txstate.departmentChemistry and Biochemistry


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