Maternal Omega-3 Fatty Acid Intake During Neurodevelopment Does Not Affect Pup Behavior Related to Depression, Novelty, or Learning
|dc.contributor.author||Jackson, Corey S. ( )|
|dc.contributor.author||Barrett, Douglas W. ( )|
|dc.contributor.author||Shumake, Jason ( https://orcid.org/0000-0003-4655-436X )|
|dc.contributor.author||Gonzales, Elisa ( )|
|dc.contributor.author||Gonzalez-Lima, F. ( )|
|dc.contributor.author||Lane, Michelle A. ( https://orcid.org/0000-0002-4801-2962 )|
|dc.identifier.citation||Jackson, C., Barrett, D. W., Shumake, J., Gonzales, E., Gonzalez-Lima, F., Lane, M. A. (2018). Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning. BMC Research Notes, 11 : 812.||en_US|
Objective: Previously, we showed that consumption of a diet supplemented with omega-3 polyunsaturated fatty acids (n-3FAs) for two rounds of gestation and lactation increased the ability of rat dams to cope with stress when compared to dams that ingested a diet lacking n-3FAs. The objective of this study was to determine if the diets of these dams affected the behavior of their pups later in life. To isolate the neurodevelopmental effects of n-3FAs, pups from the second gestation were weaned to a diet adequate in n-3FAs. Pup testing began at 8 weeks of age and consisted of the forced swim, open field, and hole board tests to examine depression-related behavior, reaction to novelty, and learning and memory, respectively.
Results: Given the considerable difference in the n-3FA content of the maternal diet, we expected a large effect size, however with the exception of rearing duration, maternal diet did not affect behavior in any of the tests conducted. These results suggest that maternal n-3FA supplementation during neurodevelopment likely does not affect offspring behavior when a diet adequate in n-3FA is provided post-weaning. Rather, we hypothesize that brain n-3FAs at the time of testing confer altered behavior and corroborate the need for additional research.
|dc.format.medium||1 file (.pdf)|
|dc.source||BMC Research Notes, 2018, Vol. 11, Article 812|
|dc.subject||n-3 fatty acids|
|dc.subject||Novelty reactivity learning|
|dc.title||Maternal Omega-3 Fatty Acid Intake During Neurodevelopment Does Not Affect Pup Behavior Related to Depression, Novelty, or Learning||en_US|
|dc.rights.holder||© 2018 The Authors.|
This work is licensed under a Creative Commons Attribution 4.0 International License.
|txstate.department||Family and Consumer Sciences|