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dc.contributor.authorLu, Yuan ( )
dc.contributor.authorBoswell, Mikki ( )
dc.contributor.authorBoswell, William T. ( )
dc.contributor.authorKneitz, Susanne ( )
dc.contributor.authorHausmann, Michael ( )
dc.contributor.authorKlotz, Barbara ( Orcid Icon 0000-0002-4988-3575 )
dc.contributor.authorRegneri, Janine ( )
dc.contributor.authorSavage, Markita G. ( )
dc.contributor.authorAmores, Angel ( )
dc.contributor.authorPostlethwait, John ( Orcid Icon 0000-0002-5476-2137 )
dc.contributor.authorWarren, Wesley C. ( )
dc.contributor.authorSchartl, Manfred ( Orcid Icon 0000-0001-9882-5948 )
dc.contributor.authorWalter, Ronald B. ( )
dc.date.accessioned2019-08-30T19:22:21Z
dc.date.available2019-08-30T19:22:21Z
dc.date.issued2018-07
dc.identifier.citationLu, Y., Boswell, M., Boswell, W., Kneitz, S., Hausmann, M., Klotz, B., Regneri, J., Savage, M., Amores, A., Postlethwait, J., Warren, W., Schartl, M., & Walter, R. (2018). Comparison of Xiphophorus and human melanoma transcriptomes reveals conserved pathway interactions. Pigment Cell and Melanoma Research, 31(4), pp. 496–508.en_US
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/8580
dc.description.abstractComparative analysis of human and animal model melanomas can uncover conserved pathways and genetic changes that are relevant for the biology of cancer cells. Spontaneous melanoma in Xiphophorus interspecies backcross hybrid progeny may be informative in identifying genes and functional pathways that are similarly related to melanoma development in all vertebrates, including humans. To assess functional pathways involved in the Xiphophorus melanoma, we performed gene expression profiling of the melanomas produced in interspecies BC1 and successive backcross generations (i.e., BC5 ) of the cross: X. hellerii × [X. maculatus Jp 163 A × X. hellerii]. Using RNA-Seq, we identified genes that are transcriptionally co-expressed with the driver oncogene, xmrk. We determined functional pathways in the fish melanoma that are also present in human melanoma cohorts that may be related to dedifferentiation based on the expression levels of pigmentation genes. Shared pathways between human and Xiphophorus melanomas are related to inflammation, cell migration, cell proliferation, pigmentation, cancer development, and metastasis. Our results suggest xmrk co-expressed genes are associated with dedifferentiation and highlight these signaling pathways as playing important roles in melanomagenesis.en_US
dc.formatText
dc.format.extent25 pages
dc.format.medium1 file (.pdf)
dc.language.isoen
dc.publisherBlackwell Publishing Ltden_US
dc.sourcePigment Cell and Melanoma Research, 2018, Vol. 1, No. 4, pp. 496–508
dc.subjectXiphophorusen_US
dc.subjectBioinformatics
dc.subjectGene expression profiling
dc.subjectMelanoma
dc.subjectSignaling transduction
dc.subjectTranscriptome
dc.subjectxmrk(EGFR)
dc.titleComparison of Xiphophorus and Human Melanoma Transcriptomes Reveals Conserved Pathway Interactionsen_US
dc.typeacceptedVersion
txstate.documenttypeArticle
dc.description.versionThis is the accepted manuscript version of an article published in Pigment Cell and Melanoma Research.
dc.identifier.doihttps://doi.org/10.1111/pcmr.12686
txstate.departmentBiology


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