Recreational Marijuana Use and Acute Myocardial Infarction: Insights from Nationwide Inpatient Sample in the United States
Date
2017-11
Authors
Desai, Rupak
Patel, Upenkumar
Sharma, Shobhit
Amin, Parth
Bhuva, Rushikkumar
Patel, Malav S.
Sharma, Nitin
Shah, Manan
Patel, Smit
Savani, Sejal
Journal Title
Journal ISSN
Volume Title
Publisher
Cureus, Inc.
Abstract
Background: Marijuana is a widely used recreational substance. Few cases have been reported of acute myocardial infarction following marijuana use. To our knowledge, this is the first ever study analyzing the lifetime odds of acute myocardial infarction (AMI) with marijuana use and the outcomes in AMI patients with versus without marijuana use.
Methods: We queried the 2010-2014 National Inpatient Sample (NIS) database for 11-70-year-old AMI patients. Pearson Chi-square test for categorical variables and Student T-test for continuous variables were used to compare the baseline demographic and hospital characteristics between two groups (without vs. with marijuana) of AMI patients. The univariate and multivariate analyses were used to assess and compare the clinical outcomes between two groups. We used Cochran-Armitage test to measure the trends. All statistical analyses were executed by IBM SPSS Statistics 22.0 (IBM Corp., Armonk, NY). We used weighted data to produce national estimates in our study.
Results: Out of 2,451,933 weighted hospitalized AMI patients, 35,771 patients with a history of marijuana and 2,416,162 patients without a history of marijuana use were identified. The AMI-marijuana group consisted more of younger, male, African American patients. The length of stay and mortality rate were lower in the AMI-marijuana group with more patients being discharged against medical advice. Multivariable analysis showed that marijuana use was a significant risk factor for AMI development when adjusted for age, sex, race (adjusted OR 1.079, 95% CI 1.065-1.093, p<0.001); adjusted for age, female, race, smoking, cocaine abuse (adjusted OR 1.041, 95% CI 1.027-1.054, p<0.001); and also when adjusted for age, female, race, payer status, smoking, cocaine abuse, amphetamine abuse and alcohol abuse (adjusted OR: 1.031, 95% CI: 1.018-1.045, p<0.001). Complications such as respiratory failure (OR 18.9, CI 15.6-23.0, p<0.001), cerebrovascular disease (OR 9.0, CI 7.0-11.7, p<0.001), cardiogenic shock (OR 6.0, CI 4.9-7.4, p<0.001), septicemia (OR 1.8, CI 1.5-2.2, p<0.001), and dysrhythmia (OR 1.8, CI 1.5-2.1, p<0.001) were independent predictors of mortality in AMI-marijuana group.
Conclusion: The lifetime AMI odds were increased in recreational marijuana users. Overall odds of mortality were not increased significantly in AMI-marijuana group. However, marijuana users showed higher trends of AMI prevalence and related mortality from 2010-2014. It is crucial to assess cardiovascular effects related to marijuana overuse and educate patients for the same.
Description
Keywords
cannabis, cardiovascular, marijuana, mortality, myocardial infarction, nationwide, recreational, substance abuse, trend, acute myocardial infarction, Biology
Citation
Desai, R., Patel, U., Sharma, S., Amin, P., Bhuva, R., Patel, M. S., Sharma, N., Shah, M., Patel, S., Savani, C., Batra, N., & Kumar, G. (2017). Recreational marijuana use and acute myocardial infarction: Insights from nationwide inpatient sample in the United States. Cureus, 9(11), e1816.
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Rights Holder
© 2017 Desai et al.
Rights License
This work is licensed under a Creative Commons Attribution 3.0 United States License.