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dc.contributor.authorGonzalez, Trevor J. ( )
dc.contributor.authorLu, Yuan ( )
dc.contributor.authorBoswell, Mikki ( )
dc.contributor.authorBoswell, William T. ( )
dc.contributor.authorMedrano, Geraldo ( )
dc.contributor.authorWalter, Sean M. ( )
dc.contributor.authorEllis, Samuel ( )
dc.contributor.authorSavage, Markita G. ( )
dc.contributor.authorVarga, Zoltan M. ( )
dc.contributor.authorLawrence, Christian ( )
dc.contributor.authorSanders, George ( )
dc.contributor.authorWalter, Ronald B. ( )
dc.date.accessioned2019-09-07T17:47:37Z
dc.date.available2019-09-07T17:47:37Z
dc.date.issued2018-09
dc.identifier.citationGonzalez, T. J., Lu, Y., Boswell, M., Boswell, W., Medrano, G., Walter, S., Ellis, S., Savage, M., Varga, Z. M., Lawrence, C., Sanders, G., & Walter, R. B. (2018). Fluorescent light exposure incites acute and prolonged immune responses in zebrafish (Danio rerio) skin. Comparative Biochemistry and Physiology, Part C, 208, pp. 87–95.en_US
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/8620
dc.description.abstractArtificial light produces an emission spectrum that is considerably different than the solar spectrum. Artificial light has been shown to affect various behavior and physiological processes in vertebrates. However, there exists a paucity of data regarding the molecular genetic effects of artificial light exposure. Previous studies showed that one of the commonly used fluorescent light source (FL; 4100K or "cool white") can affect signaling pathways related to maintenance of circadian rhythm, cell cycle progression, chromosome segregation, and DNA repair/recombination in the skin of male Xiphophorus maculatus. These observations raise questions concerning the kinetics of the FL induced gene expression response, and which biological functions become modulated at various times after light exposure. To address these questions, we exposed zebrafish to 4100K FL and utilized RNA-Seq to assess gene expression changes in skin at various times (1 to 12h) after FL exposure. We found 4100K FL incites a robust early (1-2h) transcriptional response, followed by a more protracted late response (i.e., 4-12h). The early transcriptional response involves genes associated with cell migration/infiltration and cell proliferation as part of an overall increase in immune function and inflammation. The protracted late transcriptional response occurs within gene sets predicted to maintain and perpetuate the inflammatory response, as well as suppression of lipid, xenobiotic, and melatonin metabolism.en_US
dc.formatText
dc.format.extent22 pages
dc.format.medium1 file (.pdf)
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.sourceComparative Biochemistry and Physiology, Part C, 2018, Vol. 208, pp. 87–95
dc.subjectFluorescent lighten_US
dc.subjectRNA-Seq
dc.subjectSkin
dc.subjectVertebrate
dc.subjectZebrafish
dc.titleFluorescent Light Exposure Incites Acute and Prolonged Immune Responses in Zebrafish (Danio rerio) Skinen_US
txstate.documenttypeArticle
dc.description.versionThis is the accepted manuscript version of an article published in Comparative Biochemistry and Physiology, Part C.
dc.identifier.doihttps://doi.org/10.1016/j.cbpc.2017.09.009
txstate.departmentChemistry and Biochemistry


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