Covalent Modification of Biological Targets with Natural Products through Paal-Knorr pyrrole Formation
Date
2017-08
Authors
Kornienko, Alexander
La Clair, James
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
Natural products and endogenous metabolites engage specific targets within tissues and cells through complex mechanisms. This review examines the extent to which natural systems have adopted the Paal-Knorr reaction to engage nucleophilic amine groups within biological targets. Current understanding of this mode of reactivity is limited by only a few examples of this reaction in a biological context. This highlight is intended to stimulate the scientific community to identify potential research directions and applications of the Paal-Knorr reaction in native and engineered biological systems.
Description
Keywords
natural products, endogenous metabolites, Paal-Knorr pyrrole formation, Chemistry and Biochemistry
Citation
Kornienko, A., La Clair, J. (2017). Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation. Natural Product Reports, 34(9), pp. 1051–1060.