Show simple item record

dc.contributor.authorKornienko, Alexander ( )
dc.contributor.authorLa Clair, James ( Orcid Icon 0000-0001-6500-4107 )
dc.date.accessioned2019-10-17T16:11:53Z
dc.date.available2019-10-17T16:11:53Z
dc.date.issued2017-08
dc.identifier.citationKornienko, A., La Clair, J. (2017). Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation. Natural Product Reports, 34(9), pp. 1051–1060.en_US
dc.identifier.issn0265-0568
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/8677
dc.description.abstractNatural products and endogenous metabolites engage specific targets within tissues and cells through complex mechanisms. This review examines the extent to which natural systems have adopted the Paal-Knorr reaction to engage nucleophilic amine groups within biological targets. Current understanding of this mode of reactivity is limited by only a few examples of this reaction in a biological context. This highlight is intended to stimulate the scientific community to identify potential research directions and applications of the Paal-Knorr reaction in native and engineered biological systems.en_US
dc.formatText
dc.format.extent34 pages
dc.format.medium1 file (.pdf)
dc.language.isoen
dc.publisherRoyal Society of Chemistryen_US
dc.sourceNatural Product Reports, 2017, Vol. 34, No. 9, pp. 1051–1060
dc.subjectNatural products
dc.subjectEndogenous metabolites
dc.subjectPaal-Knorr pyrrole formation
dc.titleCovalent Modification of Biological Targets with Natural Products through Paal-Knorr pyrrole Formationen_US
dc.typeacceptedVersion
txstate.documenttypeArticle
dc.description.versionThis is the accepted manuscript version of an article published in Natural Product Reports.
dc.identifier.doihttps://doi.org/10.1039/c7np00024c
txstate.departmentChemistry and Biochemistry


Download

Thumbnail

This item appears in the following Collection(s)

Show simple item record