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dc.contributor.authorDasari, Ramesh ( )
dc.contributor.authorLa Clair, James ( Orcid Icon 0000-0001-6500-4107 )
dc.contributor.authorKornienko, Alexander ( )
dc.date.accessioned2019-10-18T15:17:39Z
dc.date.available2019-10-18T15:17:39Z
dc.date.issued2017-09
dc.identifier.citationDasari, R., La Clair, J. J., & Kornienko, A. (2017). Irreversible protein labeling by Paal-Knorr conjugation. ChemBioChem, 18(18), pp. 1792–1796.en_US
dc.identifier.issn1439-4227
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/8714
dc.description.abstractThe application of new chemical reactions in a biological context has advanced bioconjugation methods for both fundamental research and commercial arenas. Recent adaptations of reactions such as Huisgen 1,3-dipolar or Diels-Alder cycloadditions have enabled the labeling of specific residues in biomolecules by the attachment of molecules carrying azides, alkynes, or strained alkenes. Although these are fundamental tools, there is a need for the discovery of reactions that can label native proteins. We report herein the adaptation of the Paal-Knorr reaction to label lysine residues in proteins via pyrrole linkages.en_US
dc.formatText
dc.format.extent15 pages
dc.format.medium1 file (.pdf)
dc.language.isoen
dc.publisherWileyen_US
dc.sourceChemBioChem, 2017, Vol. 18, No. 18, pp. 1792–1796
dc.subjectPaal-Knorr reactionen_US
dc.subjectBiocompatible reactions
dc.subjectBioconjugation
dc.subjectClick chemistry
dc.subjectProtein labeling
dc.titleIrreversible Protein Labeling by Paal-Knorr Conjugationen_US
dc.typeacceptedVersion
txstate.documenttypeArticle
dc.description.versionThis is the accepted manuscript version of an article published in ChemBioChem.
dc.identifier.doihttps://doi.org/10.1002/cbic.201700210
txstate.departmentChemistry and Biochemistry


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