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dc.contributor.authorCiavatta, Maria Letizia ( Orcid Icon 0000-0002-7308-1011 )
dc.contributor.authorLefranc, Florence ( )
dc.contributor.authorCarbone, Marianna ( )
dc.contributor.authorMollo, Ernesto ( Orcid Icon 0000-0001-7379-1788 )
dc.contributor.authorGavagnin, Margherita ( )
dc.contributor.authorBetancourt, Tania ( )
dc.contributor.authorDasari, Ramesh ( )
dc.contributor.authorKornienko, Alexander ( )
dc.contributor.authorKiss, Robert ( )
dc.date.accessioned2020-04-13T15:30:50Z
dc.date.available2020-04-13T15:30:50Z
dc.date.issued2016-12
dc.identifier.citationCiavatta, M. L., Lefranc, F., Carbone, M., Mollo, E., Gavagnin, M., Betancourt, T., Dasari, R., Kornienko, A., & Kiss, R. (2016). Marine mollusk-derived agents with antiproliferative activity as promising anticancer agents to overcome chemotherapy resistance. Medicinal Research Reviews, 37(4), pp. 702–801.en_US
dc.identifier.issn1098-1128
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/9588
dc.description.abstractThe chemical investigation of marine mollusks has led to the isolation of a wide variety of bioactive metabolites, which evolved in marine organisms as favorable adaptations to survive in different environments. Most of them are derived from food sources, but they can be also biosynthesized de novo by the mollusks themselves, or produced by symbionts. Consequently, the isolated compounds cannot be strictly considered as "chemotaxonomic markers" for the different molluscan species. However, the chemical investigation of this phylum has provided many compounds of interest as potential anticancer drugs that assume particular importance in the light of the growing literature on cancer biology and chemotherapy. The current review highlights the diversity of chemical structures, mechanisms of action, and, most importantly, the potential of mollusk-derived metabolites as anticancer agents, including those biosynthesized by mollusks and those of dietary origin. After the discussion of dolastatins and kahalalides, compounds previously studied in clinical trials, the review covers potentially promising anticancer agents, which are grouped based on their structural type and include terpenes, steroids, peptides, polyketides and nitrogen-containing compounds. The "promise" of a mollusk-derived natural product as an anticancer agent is evaluated on the basis of its ability to target biological characteristics of cancer cells responsible for poor treatment outcomes. These characteristics include high antiproliferative potency against cancer cells in vitro, preferential inhibition of the proliferation of cancer cells over normal ones, mechanism of action via nonapoptotic signaling pathways, circumvention of multidrug resistance phenotype, and high activity in vivo, among others. The review also includes sections on the targeted delivery of mollusk-derived anticancer agents and solutions to their procurement in quantity.en_US
dc.formatText
dc.format.extent100 pages
dc.format.medium1 file (.pdf)
dc.language.isoen
dc.publisherWiley Periodicals, Inc.
dc.sourceMedicinal Research Reviews, 2016, Vol. 37, No. 4, pp. 702–801
dc.subjectInnovative mechanism of actionen_US
dc.subjectMollusk
dc.subjectCancer
dc.subjectPreclinical evaluation
dc.subjectTargeted delivery
dc.subjectTreatment
dc.titleMarine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistanceen_US
txstate.documenttypeArticle
dc.identifier.doihttps://doi.org/10.1002/med.21423
dc.rights.license© 2016 The Authors Medicinal Research Reviews Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
txstate.departmentChemistry and Biochemistry


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