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dc.contributor.authorMa, Hang ( )
dc.contributor.authorDaSilva, Nicholas A. ( Orcid Icon 0000-0003-1925-0790 )
dc.contributor.authorLiu, Weixi ( )
dc.contributor.authorNahar, Pragati P. ( )
dc.contributor.authorWei, Zhengxi ( )
dc.contributor.authorLiu, Yongqiang ( )
dc.contributor.authorPham, Priscilla T. ( )
dc.contributor.authorCrews, Rebecca ( )
dc.contributor.authorVattem, Dhiraj ( )
dc.contributor.authorSlitt, Angela L. ( )
dc.contributor.authorShaikh, Zahir A. ( )
dc.contributor.authorSeeram, Navindra ( Orcid Icon 0000-0001-7064-2904 )
dc.date.accessioned2020-04-13T21:19:50Z
dc.date.available2020-04-13T21:19:50Z
dc.date.issued2016-11
dc.identifier.citationMa, H., DaSilva, N. A., Liu, W., Nahar, P. P., Wei, Z., Liu, Y., Pham, P. T., Crews, R., Vattem, D. A., Slitt, A. L., Shaikh, Z. A., & Seeram, N. P. (2016). Effects of a standardized phenolic-enriched maple syrup extract on β-amyloid aggregation, neuroinflammation in microglial and neuronal cells, and β-amyloid induced neurotoxicity in Caenorhabditis elegans. Neurochemical Research, 41(11), pp. 2836-2847.en_US
dc.identifier.issn0364-3190
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/9593
dc.description.abstractPublished data supports the neuroprotective effects of several phenolic-containing natural products, including certain fruit, berries, spices, nuts, green tea, and olive oil. However, limited data are available for phenolic-containing plant-derived natural sweeteners including maple syrup. Herein, we investigated the neuroprotective effects of a chemically standardized phenolic-enriched maple syrup extract (MSX) using a combination of biophysical, in vitro, and in vivo studies. Based on biophysical data (Thioflavin T assay, transmission electron microscopy, circular dichroism, dynamic light scattering, and zeta potential), MSX reduced amyloid β1-42 peptide (Aβ1-42) fibrillation in a concentration-dependent manner (50-500 μg/mL) with similar effects as the neuroprotective polyphenol, resveratrol, at its highest test concentration (63.5 % at 500 μg/mL vs. 77.3 % at 50 μg/mL, respectively). MSX (100 μg/mL) decreased H2O2-induced oxidative stress (16.1 % decrease in ROS levels compared to control), and down-regulated the production of lipopolysaccharide (LPS)-stimulated inflammatory markers (22.1, 19.9, 74.8, and 87.6 % decrease in NOS, IL-6, PGE2, and TNFα levels, respectively, compared to control) in murine BV-2 microglial cells. Moreover, in a non-contact co-culture cell model, differentiated human SH-SY5Y neuronal cells were exposed to conditioned media from BV-2 cells treated with MSX (100 μg/mL) and LPS or LPS alone. MSX-BV-2 media increased SH-SY5Y cell viability by 13.8 % compared to media collected from LPS-BV-2 treated cells. Also, MSX (10 μg/mL) showed protective effects against Aβ1-42 induced neurotoxicity and paralysis in Caenorhabditis elegans in vivo. These data support the potential neuroprotective effects of MSX warranting further studies on this natural product.en_US
dc.formatText
dc.format.extent23 pages
dc.format.medium1 file (.pdf)
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.sourceNeurochemical Research, 2016, Vol. 41, No. 11, pp. 2836-2847.
dc.subjectAlzheimer’s diseaseen_US
dc.subjectAmyloid β1−42
dc.subjectCaenorhabditis elegans
dc.subjectMaple syrup phenolics
dc.subjectNeuroinflammation
dc.subjectNeuroprotective
dc.titleEffects of a Standardized Phenolic-Enriched Maple Syrup Extract on β-Amyloid Aggregation, Neuroinflammation in Microglial and Neuronal Cells, and β-Amyloid Induced Neurotoxicity in Caenorhabditis elegansen_US
txstate.documenttypeArticle
dc.description.versionThis is the accepted manuscript version of an article published in Neurochemical Research.
dc.identifier.doihttps://doi.org/10.1007/s11064-016-1998-6
txstate.departmentFamily and Consumer Sciences


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