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dc.contributor.advisorGarcia, Dana M.
dc.contributor.authorCopeland, Chad Michael ( )
dc.identifier.citationCopeland, C. M. (2005). Muscarinic receptor subtypes involved in pigment granule dispersion in retinal pigment epithelium (Unpublished thesis). Texas State University-San Marcos, San Marcos, Texas.
dc.description.abstractPrevious studies have shown muscarinic receptors are involved in light driven pigment dispersion in retinal pigment epithelia (RPE). Pharmacological agents can be used to test this hypothesis and by selective inhibition, elucidate the sub-class of the receptor involved, and the intracellular downstream signaling pathway. RPE was isolated from Lepomis macrochirus, commonly known as bluegill, and treated with various pharmacological agents, including muscarinic receptor antagonists and agents to block second messenger pathway targets. Telenzepine and p-FHHSiD, M1 and M3 receptor antagonists, respectively, blocked pigment granule dispersion induced by carbachol, while methoctramine, an M2 antagonist did not. U73122 and 2-APB, a phospholipase C inhibitor and IP3-receptor antagonist, respectively, were also able to block carbachol-induce dispersion. Therefore, I conclude that carbachol-induced pigment dispersion 1s mediated through Motltl receptors. I also propose that Ca2+ could be necessary for pigment dispersion mduced by carbachol.
dc.format.extent71 pages
dc.format.medium1 file (.pdf)
dc.subjectMuscarinic receptors
dc.titleMuscarinic Receptor Subtypes Involved in Pigment Granule Dispersion in Retinal Pigment Epithelium
txstate.documenttypeThesis State University--San Marcos of Science


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