Fluorescent Light Incites a Conserved Immune and Inflammatory Genetic Response within Vertebrate Organs (Danio rerio, Oryzias latipes and Mus musculus)

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dc.contributor.authorBoswell, Mikki
dc.contributor.authorLu, Yuan
dc.contributor.authorSavage, Markita G.
dc.contributor.authorHildreth, Kim
dc.contributor.authorSalinas, Raquel
dc.contributor.authorWalter, Christi A.
dc.contributor.authorWalter, Ronald B.
dc.date.accessioned2019-07-30T17:50:28Z
dc.date.available2019-07-30T17:50:28Z
dc.date.issued2019-04
dc.description.abstractFluorescent light (FL) has been utilized for ≈60 years and has become a common artificial light source under which animals, including humans, spend increasing amounts of time. Although the solar spectrum is quite dissimilar in both wavelengths and intensities, the genetic consequences of FL exposure have not been investigated. Herein, we present comparative RNA-Seq results that establish expression patterns within skin, brain, and liver for Danio rerio, Oryzias latipes, and the hairless mouse (Mus musculus) after exposure to FL. These animals represent diurnal and nocturnal lifestyles, and ≈450 million years of evolutionary divergence. In all three organisms, FL induced transcriptional changes of the acute phase response signaling pathway and modulated inflammation and innate immune responses. Our pathway and gene clustering analyses suggest cellular perception of oxidative stress is promoting induction of primary up-stream regulators IL1B and TNF. The skin and brain of the three animals as well as the liver of both fish models all exhibit increased inflammation and immune responses; however, the mouse liver suppressed the same pathways. Overall, the conserved nature of the genetic responses observed after FL exposure, among fishes and a mammal, suggest the presence of light responsive genetic circuitry deeply embedded in the vertebrate genome.
dc.description.departmentChemistry and Biochemistry
dc.formatText
dc.format.extent25 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationBoswell, M., Lu, Y., Boswell, W., Savage, M., Hildreth, K., Salinas, R., Walter, C. A., & Walter, R. B. (2019). Fluorescent Light Incites a Conserved Immune and Inflammatory Genetic Response within Vertebrate Organs (Danio rerio, Oryzias latipes and Mus musculus). Genes, 10(4): 271.
dc.identifier.doihttps://doi.org/10.3390/genes10040271
dc.identifier.urihttps://hdl.handle.net/10877/8421
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute
dc.rights.holder© 2019 The Authors.
dc.rights.licenseThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.sourceGenes, 2019, Vol. 10, No. 4, Article 271.
dc.subjectRNA-Seq
dc.subjectfluorescent light
dc.subjectacute phase
dc.subjectoxidative stress
dc.subjectgene expression
dc.subjectChemistry and Biochemistry
dc.titleFluorescent Light Incites a Conserved Immune and Inflammatory Genetic Response within Vertebrate Organs (Danio rerio, Oryzias latipes and Mus musculus)
dc.typeArticle

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