Synthetic Analogues of the Montanine-type Alkaloids with Activity Against Apoptosis-resistant Cancer Cells

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dc.contributor.authorGovindaraju, Karthik
dc.contributor.authorIngels, Aude
dc.contributor.authorHasan, Md Nabiul
dc.contributor.authorSun, Dandan
dc.contributor.authorMathieu, Veronique
dc.contributor.authorMasi, Marco
dc.contributor.authorEvidente, Antonio
dc.contributor.authorKornienko, Alexander
dc.date.accessioned2019-08-28T18:27:46Z
dc.date.available2019-08-28T18:27:46Z
dc.date.issued2018-02
dc.description.abstractIn a search of small molecules active against apoptosis-resistant cancer cells, a skeletal rearrangement of alkaloid haemanthamine was utilized to generate a series of compounds possessing the alkaloid montanine ring system. The synthesized compounds were found to inhibit proliferation of cancer cells resistant to apoptosis at micromolar concentrations. Selected compounds were also active against patient-derived glioblastoma cells expressing stem-cell markers. This is the first report describing the preparation of synthetic analogues of the montanine-type alkaloids with antiproliferative activity. The compounds prepared in the current investigation appear to be a useful starting point for the development of agents to fight cancers with apoptosis resistance, and thus, associated with poor prognoses.
dc.description.departmentChemistry and Biochemistry
dc.description.versionThis is the accepted author manuscript version of an article published in Bioorganic and Medicinal Chemistry Letters.
dc.formatText
dc.format.extent13 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationGovindaraju, K., Ingels, A., Hasan, M. N., Sun, D., Mathieu, V., Masi, M., Evidente, A., & Kornienko, A. (2018). Synthetic analogues of the montanine-type alkaloids with activity against apoptosis-resistant cancer cells. Bioorganic and Medicinal Chemistry Letters, 28(4), pp. 589–593.
dc.identifier.doihttps://doi.org/10.1016/j.bmcl.2018.01.041
dc.identifier.urihttps://hdl.handle.net/10877/8559
dc.language.isoen
dc.publisherElsevier
dc.sourceBioorganic and Medicinal Chemistry Letters, 2018, Vol. 28, No. 4, pp. 589–593.
dc.subjectapoptosis resistance
dc.subjectmontanine
dc.subjecthaemanthamine
dc.subjectmanthine
dc.subjectantiproliferative activity
dc.subjectChemistry and Biochemistry
dc.titleSynthetic Analogues of the Montanine-type Alkaloids with Activity Against Apoptosis-resistant Cancer Cells
dc.typeArticle

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