Synthesis and Evaluation of a Rationally Designed Click-Based Library for G-Quadruplex Selective DNA Photocleavage

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dc.contributor.authorMcBrayer, Dominic
dc.contributor.authorKerwin, Sean M.
dc.date.accessioned2020-05-16T19:05:55Z
dc.date.available2020-05-16T19:05:55Z
dc.date.issued2015-09
dc.description.abstractDNA containing repeating G-rich sequences can adopt higher-order structures known as G-quadruplexes (G4). These structures are believed to form within telomeres and the promoter regions of some genes, particularly in a number of proto-oncogenes, where they may play a role in regulating transcription. Alternatively, G4 DNA may act as a barrier to replication. To investigate these potential biological roles, probes that combine highly selective G4 DNA targeting with photocleavage activity can allow temporal detection of G4 DNA, providing opportunities to obtain novel insights about the biological roles of G4 DNA. We have designed, synthesized, and screened a small library of potential selective G-quadruplex DNA photocleavage agents incorporating the G-quadruplex targeting moiety of 360A with known photocleavage groups linked via “click” chemistry.
dc.description.departmentChemistry and Biochemistry
dc.formatText
dc.format.extent20 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationMcBrayer, D., & Kerwin, S. M. (2015). Synthesis and evaluation of a rationally designed click-based library for G-quadruplex selective DNA photocleavage. Molecules, 20(9), pp. 16446-16465.
dc.identifier.doihttps://doi.org/10.3390/molecules200916446
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/10877/9944
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute
dc.rights.licenseThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.sourceMolecules, 2015, Vol. 20, No. 9, pp. 16446-16465.
dc.subjectDNA
dc.subjectPhotocleavage
dc.subjectAlkyne-azide click reaction
dc.subjectPAGE
dc.titleSynthesis and Evaluation of a Rationally Designed Click-Based Library for G-Quadruplex Selective DNA Photocleavage
dc.typeArticle

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