Prebiotic, Immuno-Stimulating and Gut Microbiota-Modulating Effects of Lycium Barbarum Polysaccharide

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dc.contributor.authorZhu, Wei
dc.contributor.authorZhou, Shuxin
dc.contributor.authorLiu, Jihua
dc.contributor.authorMcLean, Robert J. C.
dc.contributor.authorChu, Weihua
dc.date.accessioned2020-03-12T14:16:59Z
dc.date.available2020-03-12T14:16:59Z
dc.date.issued2020-01
dc.description.abstractThe present study was done to evaluate the prebiotic effect of Lycium barbarum polysaccharide (LBP), its effect on murine fecal microbiota composition and innate immune response. Results showed that LBP supports the growth of selective probiotic bacteria with a maximum of 8.23 (log10 cfu/mL) and 6.62 (log10 cfu/mL) for Lactobacillus acidophilus and Bifidobacterium longum respectively. In vivo studies revealed that the administrations of LBP to mice resulted in an increase in the abundance of the phyla Proteobacteria and Firmicutes, while reducing the ratio of the phylum Bacteroidetes. At the genus level, the administration of LBP stimulated the emergence of some potential probiotic genera (Akkermansia, Lactobacillus, and Prevotellaceae). The concentrations of TGF-β and IL-6 in serum and sIgA in the colon content were enriched significantly after LBP administrations in mice. The thymus index and spleen index of mice treated with LBP displayed significant difference compared to the control group (P < 0.05). These findings suggest that LBP is a good source as a potential prebiotic and can enhance the intestinal microbiota and boost beneficial bacteria levels, modulate innate immune response.
dc.description.departmentBiology
dc.formatText
dc.format.extent6 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationZhu, W., Zhou, S., Liu, J., McLean, R. J. C., & Chu, W. (2020). Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide. Biomedicine and Pharmacotherapy, 121.
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2019.109591
dc.identifier.issn1950-6007
dc.identifier.urihttps://hdl.handle.net/10877/9387
dc.language.isoen
dc.publisherElsevier
dc.rights.holder© 2019 The Authors.
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
dc.sourceBiomedicine and Pharmacotherapy, 2020, Vol. 121, Article 109591.
dc.subjectintestinal microbiota
dc.subjectLycium barbarum polysaccharide
dc.subjectprebiotic activity
dc.subjectinnate immune
dc.subjectBiology
dc.titlePrebiotic, Immuno-Stimulating and Gut Microbiota-Modulating Effects of Lycium Barbarum Polysaccharide
dc.typeArticle

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