The Effects of Methanol and Isopropanol on the Chiral Separation of Dronabinol and Three Related Impurities: A 3 X 3 X 3 Factorial Design

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dc.contributor.advisorBatey, Andy
dc.contributor.authorTarbox, Tamara N.
dc.contributor.committeeMemberDilek, Isil
dc.contributor.committeeMemberRudzinski, Walter
dc.date.accessioned2012-07-19T19:58:28Z
dc.date.available2012-07-19T19:58:28Z
dc.date.issued2010-05
dc.description.abstractThe enantioseparations of Δ9-THC and Δ8-THC on amylose tris dimethylphenylcarbamate CSP was investigated using mobile phases containing 1-3% methanol with 1-7% IPA in n-heptane. A factorial design was used to study the main and interaction effects of these alcohols as measured by the retention time, selectivity, and resolution of each pair of enantiomers, as well as the critical pair: (+)-Δ9-THC and (-)-Δ8-THC. Methanol did not significantly affect the enantioseparation of the critical pair, while the interaction effect was significant in all cases. An elution order reversal for Δ8-THC was noted at 1% IPA with 2-3% methanol, and excluding these conditions, Δ9-THC resolution was greater than 5.0 in all other cases.
dc.description.departmentEngineering Technology
dc.formatText
dc.format.extent151 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationTarbox, T. N. (2010). The effects of methanol and isopropanol on the chiral separation of Dronabinol and three related impurities: A 3 X 3 X 3 Factorial Design</i> (Unpublished thesis). Texas State University-San Marcos, San Marcos, Texas.
dc.identifier.urihttps://hdl.handle.net/10877/4263
dc.language.isoen
dc.subjectEnantioseparation
dc.subjectChiral
dc.subjectADMPC
dc.subjectAmylosetrisdimethylphenylcarbamate
dc.subjectEnantiomer
dc.titleThe Effects of Methanol and Isopropanol on the Chiral Separation of Dronabinol and Three Related Impurities: A 3 X 3 X 3 Factorial Design
dc.typeThesis
thesis.degree.departmentEngineering Technology
thesis.degree.disciplineEngineering Technology
thesis.degree.grantorTexas State University-San Marcos
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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