Irreversible Protein Labeling by Paal-Knorr Conjugation
| dc.contributor.author | Dasari, Ramesh | |
| dc.contributor.author | La Clair, James | |
| dc.contributor.author | Kornienko, Alexander | |
| dc.date.accessioned | 2019-10-18T15:17:39Z | |
| dc.date.available | 2019-10-18T15:17:39Z | |
| dc.date.issued | 2017-09 | |
| dc.description.abstract | The application of new chemical reactions in a biological context has advanced bioconjugation methods for both fundamental research and commercial arenas. Recent adaptations of reactions such as Huisgen 1,3-dipolar or Diels-Alder cycloadditions have enabled the labeling of specific residues in biomolecules by the attachment of molecules carrying azides, alkynes, or strained alkenes. Although these are fundamental tools, there is a need for the discovery of reactions that can label native proteins. We report herein the adaptation of the Paal-Knorr reaction to label lysine residues in proteins via pyrrole linkages. | |
| dc.description.department | Chemistry and Biochemistry | |
| dc.description.version | This is the accepted manuscript version of an article published in ChemBioChem. | |
| dc.format | Text | |
| dc.format.extent | 15 pages | |
| dc.format.medium | 1 file (.pdf) | |
| dc.identifier.citation | Dasari, R., La Clair, J. J., & Kornienko, A. (2017). Irreversible protein labeling by Paal-Knorr conjugation. ChemBioChem, 18(18), pp. 1792–1796. | |
| dc.identifier.doi | https://doi.org/10.1002/cbic.201700210 | |
| dc.identifier.issn | 1439-4227 | |
| dc.identifier.uri | https://hdl.handle.net/10877/8714 | |
| dc.language.iso | en | |
| dc.publisher | Wiley | |
| dc.source | ChemBioChem, 2017, Vol. 18, No. 18, pp. 1792–1796. | |
| dc.subject | biocompatible reactions | |
| dc.subject | bioconjugation | |
| dc.subject | click chemistry | |
| dc.subject | protein labeling | |
| dc.subject | Paal-Knorr reaction | |
| dc.subject | Chemistry and Biochemistry | |
| dc.title | Irreversible Protein Labeling by Paal-Knorr Conjugation | |
| dc.type | Article |