Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract

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dc.contributor.authorLu, Yuan
dc.contributor.authorStarkey, Nicholas
dc.contributor.authorLei, Wei
dc.contributor.authorLi, Jilong
dc.contributor.authorCheng, Jianlin
dc.contributor.authorFolk, William R.
dc.contributor.authorLubahn, Dennis
dc.date.accessioned2021-08-09T21:29:20Z
dc.date.available2021-08-09T21:29:20Z
dc.date.issued2015-12-28
dc.description.abstractSutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog (Hh)-signaling in prostate cancer cells and used RNA-Seq transcription profiling to profile gene expression in TRAMPC2 murine prostate cancer cells with or without Sutherlandia extracts. We found 50% of Hh-responsive genes can be repressed by Sutherlandia ethanol extract, including the canonical Hh-responsive genes Gli1 and Ptch1 as well as newly distinguished Hh-responsive genes Hsd11b1 and Penk.
dc.description.departmentChemistry and Biochemistry
dc.formatText
dc.format.extent9 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationLu, Y., Starkey, N., Lei, W., Li, J., Cheng, J., Folk, W. R., & Lubahn, D. B. (2015). Inhibition of hedgehog-signaling driven genes in prostate cancer cells by Sutherlandia frutescens extract. PLoS One, 10(12), e0145507.
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0145507
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10877/14260
dc.language.isoen
dc.publisherPublic Library of Science
dc.rights.holder© 2015 Lu et al.
dc.rights.licenseThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.sourcePLoS One, 2015, Vol. 10, No. 12, Article e0145507.
dc.subjectprostate cancer
dc.subjectgene expression
dc.subjectcancer treatment
dc.subjectcolorectal cancer
dc.subjectsmall cell lung cancer
dc.subjectgene ontologies
dc.subjectethanol
dc.subjectprostate gland
dc.subjectChemistry and Biochemistry
dc.titleInhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract
dc.typeArticle

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