Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem"

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dc.contributor.authorGomes, Nelson G. M
dc.contributor.authorDasari, Ramesh
dc.contributor.authorChandra, Sunena
dc.contributor.authorKiss, Robert
dc.contributor.authorKornienko, Alexander
dc.date.accessioned2020-05-26T15:49:50Z
dc.date.available2020-05-26T15:49:50Z
dc.date.issued2016-05
dc.description.abstractMarine invertebrates provide a rich source of metabolites with anticancer activities and several marine-derived agents have been approved for the treatment of cancer. However, the limited supply of promising anticancer metabolites from their natural sources is a major hurdle to their preclinical and clinical development. Thus, the lack of a sustainable large-scale supply has been an important challenge facing chemists and biologists involved in marine-based drug discovery. In the current review we describe the main strategies aimed to overcome the supply problem. These include: marine invertebrate aquaculture, invertebrate and symbiont cell culture, culture-independent strategies, total chemical synthesis, semi-synthesis, and a number of hybrid strategies. We provide examples illustrating the application of these strategies for the supply of marine invertebrate-derived anticancer agents. Finally, we encourage the scientific community to develop scalable methods to obtain selected metabolites, which in the authors’ opinion should be pursued due to their most promising anticancer activities.
dc.description.departmentChemistry and Biochemistry
dc.formatText
dc.format.extent39 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationGomes, N. G. M., Dasari, R., Chandra, S., Kiss, R., & Kornienko, A. (2016). Marine invertebrate metabolites with anticancer activities: Solutions to the "supply problem." Marine Drugs, 14(5): 98.
dc.identifier.doihttps://doi.org/10.3390/md14050098
dc.identifier.issn1660-3397
dc.identifier.urihttps://hdl.handle.net/10877/10311
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute
dc.rights.holder© 2016 The Authors.
dc.rights.licenseThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.sourceMarine Drugs, 2016, Vol. 14, No. 5, Article 98.
dc.subjecteribulin
dc.subjecttrabectedin
dc.subjectmycalamide A
dc.subjectspongistatin 1
dc.subjectstelletin A
dc.subjectmonanchocidin A
dc.subjectphenylmethylene hydantoin
dc.subjectfrondoside A
dc.subjectdiscodermolide
dc.subjectChemistry and Biochemistry
dc.titleMarine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem"
dc.typeArticle

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