Clonal Polymorphism and High Heterozygosity in the Celibate Genome of the Amazon Molly

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dc.contributor.authorWarren, Wesley C.
dc.contributor.authorGarcia-Perez, Raquel
dc.contributor.authorXu, Sen
dc.contributor.authorLampert, Kathrin P.
dc.contributor.authorChalopin, Domitille
dc.contributor.authorStock, Matthias
dc.contributor.authorLoewe, Laurence
dc.contributor.authorLu, Yuan
dc.contributor.authorKuderna, Lukas
dc.contributor.authorMinx, Patrick
dc.contributor.authorMontague, Michael J.
dc.contributor.authorTomlinson, Chad
dc.contributor.authorHillier, LaDeana W.
dc.contributor.authorMurphy, Daniel N.
dc.contributor.authorWang, John
dc.contributor.authorWang, Zhongwei
dc.contributor.authorGarcia, Constantino Macias
dc.contributor.authorThomas, Gregg W. C.
dc.contributor.authorVolff, Jean-Nicolas
dc.contributor.authorFarias, Fabiana
dc.contributor.authorAken, Bronwen
dc.contributor.authorWalter, Ronald B.
dc.contributor.authorPruitt, Kim D.
dc.contributor.authorMarques-Bonet, Tomas
dc.contributor.authorHahn, Matthew W.
dc.contributor.authorKneitz, Susanne
dc.contributor.authorLynch, Michael
dc.contributor.authorSchartl, Manfred
dc.date.accessioned2019-08-27T17:27:47Z
dc.date.available2019-08-27T17:27:47Z
dc.date.issued2018-04
dc.description.abstractThe extreme rarity of asexual vertebrates in nature is generally explained by genomic decay due to absence of meiotic recombination, thus leading to extinction of such lineages. We explore features of a vertebrate asexual genome, the Amazon molly, Poecilia formosa, and find few signs of genetic degeneration but unique genetic variability and ongoing evolution. We uncovered a substantial clonal polymorphism and, as a conserved feature from its interspecific hybrid origin, a 10-fold higher heterozygosity than in the sexual parental species. These characteristics seem to be a principal reason for the unpredicted fitness of this asexual vertebrate. Our data suggest that asexual vertebrate lineages are scarce not because they are at a disadvantage, but because the genomic combinations required to bypass meiosis and to make up a functioning hybrid genome are rarely met in nature.
dc.description.departmentChemistry and Biochemistry
dc.description.versionThis is the accepted manuscript version of an article published in Nature, Ecology, and Evolution.
dc.formatText
dc.format.extent28 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationWarren, W. C., Garcia-Perez, R., Xu, S., Lampert, K. P., Chalopin, D., Stock, M., Loewe, L., Lu, Y., Kuderna, L., Minx, P., Montague, M. J., Tomlinson, C., Hillier, L. W., Murphy, D. N., Wang, J., Wang, Z., Garcia, C. M., Thomas, G. W. C., Volff, J. N., Farias, F., Aken, B., Walter, R. B., Pruitt, K. D., Marques-Bonet, T., Hahn, M. W., Kneitz, S., Lynch, M., & Scharti, M. (2018). Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly. Nature Ecology and Evolution, 2(4), pp. 669–679.
dc.identifier.doihttps://doi.org/10.1038/s41559-018-0473-y
dc.identifier.urihttps://hdl.handle.net/10877/8553
dc.language.isoen
dc.publisherNature Publishing Group
dc.sourceNature Ecology and Evolution, 2018, Vol. 2, No. 4, pp. 669–679.
dc.subjectgenome decay
dc.subjectclonal diversity
dc.subjectameiosis
dc.subjecthybrid genome
dc.subjectintrogression
dc.subjectimmune genes
dc.subjectasexual reproduction
dc.subjectChemistry and Biochemistry
dc.titleClonal Polymorphism and High Heterozygosity in the Celibate Genome of the Amazon Molly
dc.typeArticle

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