Low Serum Carotenoids Are Associated with Self-Reported Cognitive Dysfunction and Inflammatory Markers in Breast Cancer Survivors

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dc.contributor.authorZuniga, Krystle E.
dc.contributor.authorMoran, Nancy E.
dc.date.accessioned2019-08-20T19:24:52Z
dc.date.available2019-08-20T19:24:52Z
dc.date.issued2018-08
dc.description.abstractBackground: Dietary carotenoids may exert anti-inflammatory activities to reduce inflammation-driven cognitive impairments during cancer and cancer treatment. Our objective was to explore if cognitive function in breast cancer survivors (BCS) differs by serum carotenoid concentrations, and if blood carotenoids concentrations are associated with reduced systemic inflammation. Methods: Objective cognitive function and perceived cognitive impairment of 29 BCS and 38 controls were assessed cross-sectionally with the National Institutes of Health Toolbox Cognition Battery and The Functional Assessment of Cancer Therapy-Cognitive Function Questionnaire, respectively. Serum carotenoid and inflammatory marker (sTNF-RII, IL-6, IL-1ra, CRP) concentrations were measured. Results: Low-carotenoid BCS had more cognitive complaints compared to the low-carotenoid controls (Mdiff = −43.0, p < 0.001) and high-carotenoid controls (Mdiff = −44.5, p < 0.001). However, the cognitive complaints of high-carotenoid BCS were intermediate to and not different than the low-carotenoid BCS, or low- or high-carotenoid controls. BCS performed similarly to controls on all objective cognitive measures. Multiple linear regression, controlling for age and body mass index (BMI), demonstrated an inverse association between serum carotenoid concentrations and pro-inflammatory sTNFR-II (β = 0.404, p = 0.005) and IL-6 concentrations (β = −0.35, p = 0.001), but not IL-1ra or CRP. Conclusions: Higher serum carotenoid concentrations may convey cognitive and anti-inflammatory benefits in BCS. Future research should identify dietary components and patterns that support cognitive health in cancer survivors.
dc.description.departmentFamily and Consumer Sciences
dc.formatText
dc.format.extent15 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationZuniga, K. E., & Moran, N. E. (2018). Low serum carotenoids are associated with self-reported cognitive dysfunction and inflammatory markers in breast cancer survivors. Nutrients, 10(8): 1111.
dc.identifier.doihttps://doi.org/10.3390/nu10081111
dc.identifier.issn2072-6643
dc.identifier.urihttps://hdl.handle.net/10877/8531
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute
dc.rights.holder© 2018 The Authors.
dc.rights.licenseThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.sourceNutrients, 2018, Vol. 10, No. 8, Article 1111.
dc.subjectcognition
dc.subjectcarotenoid
dc.subjectmemory
dc.subjectinflammation
dc.subjectcancer-related cognitive impairment
dc.subjectFamily and Consumer Sciences
dc.titleLow Serum Carotenoids Are Associated with Self-Reported Cognitive Dysfunction and Inflammatory Markers in Breast Cancer Survivors
dc.typeArticle

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