Jonquailine, A New Pretazettine-Type Alkaloid Isolated from Narcissus Jonquilla Quail, with Activity Against Drug-Resistant Cancer

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dc.contributor.authorMasi, Marco
dc.contributor.authorFrolova, Liliya V.
dc.contributor.authorYu, Xiaojie
dc.contributor.authorMathieu, Veronique
dc.contributor.authorCimmino, Alessio
dc.contributor.authorDe Carvalho, Annelise
dc.contributor.authorKiss, Robert
dc.contributor.authorRogelj, Snezna
dc.contributor.authorPertsemlidis, Alexander
dc.contributor.authorKornienko, Alexander
dc.contributor.authorEvidente, Antonio
dc.date.accessioned2020-03-19T17:26:54Z
dc.date.available2020-03-19T17:26:54Z
dc.date.issued2015-04
dc.description.abstractA new alkaloid, belonging to the pretazettine group of Amaryllidaceae alkaloids, was isolated from dried bulbs of Narcissus jonquilla quail and named jonquailine. Its structure, including the absolute configuration, was elucidated using various NMR, ECD and ESI MS techniques. Initial biological evaluation revealed significant antiproliferative effects against glioblastoma, melanoma, uterine sarcoma and non-small-cell lung cancer cells displaying various forms of drug resistance, including resistance to apoptosis and multi-drug resistance. Jonquailine was also found to synergize with paclitaxel in its antiproliferative action against drug-resistant lung cancer cells. The results obtained compared with literature data also showed that the hydroxylation at C-8 is an important feature for the anticancer activity but this seems unaffected by the stereochemistry or the acetalization of the lactol.
dc.description.departmentChemistry and Biochemistry
dc.description.versionThis is the accepted manuscript version of an article published in Fitoterapia.
dc.formatText
dc.format.extent19 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationMasi, M., Frolova, L. V., Yu, X., Mathieu, V., Cimmino, A., De Carvalho, A., Kiss, R., Rogelj, S., Pertsemlidis, A., Kornienko, A., & Evidente, A. (2015). Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer. Fitoterapia, 102, pp. 41–48.
dc.identifier.doihttps://doi.org/10.1016/j.fitote.2015.01.009
dc.identifier.issn0367-326X
dc.identifier.urihttps://hdl.handle.net/10877/9470
dc.language.isoen
dc.publisherElsevier
dc.sourceFitoterapia, 2015, Vol. 102, pp. 41–48.
dc.subjectamaryllidaceae
dc.subjectantiproliferative effects
dc.subjectcancer cells
dc.subjectjonquailine
dc.subjectNarcissus jonquilla quail
dc.subjectalkaloids
dc.subjectChemistry and Biochemistry
dc.titleJonquailine, A New Pretazettine-Type Alkaloid Isolated from Narcissus Jonquilla Quail, with Activity Against Drug-Resistant Cancer
dc.typeArticle

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