Preparation and Utility of N-Alkynyl Azoles in Synthesis
| dc.contributor.author | Reinus, Brandon | |
| dc.contributor.author | Kerwin, Sean M. | |
| dc.date.accessioned | 2019-07-31T17:59:21Z | |
| dc.date.available | 2019-07-31T17:59:21Z | |
| dc.date.issued | 2019-01 | |
| dc.description.abstract | Heteroatom-substituted alkynes have attracted a significant amount of interest in the synthetic community due to the polarized nature of these alkynes and their utility in a wide range of reactions. One specific class of heteroatom-substituted alkynes combines this utility with the presence of an azole moiety. These N-alkynyl azoles have been known for nearly 50 years, but recently there has been a tremendous increase in the number of reports detailing the synthesis and utility of this class of compound. While much of the chemistry of N-alkynyl azoles mirrors that of the more extensively studied N-alkynyl amides (ynamides), there are notable exceptions. In addition, as azoles are extremely common in natural products and pharmaceuticals, these N-alkynyl azoles have high potential for accessing biologically important compounds. In this review, the literature reports of N-alkynyl azole synthesis, reactions, and uses have been assembled. Collectively, these reports demonstrate the growth in this area and the promise of exploiting N-alkynyl azoles in synthesis. | |
| dc.description.department | Chemistry and Biochemistry | |
| dc.format | Text | |
| dc.format.extent | 56 pages | |
| dc.format.medium | 1 file (.pdf) | |
| dc.identifier.citation | Reinus, B., & Kerwin, S. M. (2019). Preparation and Utility of N-Alkynyl Azoles in Synthesis. Molecules, 24(3): 422. | |
| dc.identifier.doi | https://doi.org/10.3390/molecules24030422 | |
| dc.identifier.uri | https://hdl.handle.net/10877/8434 | |
| dc.language.iso | en | |
| dc.publisher | Multidisciplinary Digital Publishing Institute | |
| dc.rights.holder | © 2019 The Authors. | |
| dc.rights.license | This work is licensed under a Creative Commons Attribution 4.0 International License. | |
| dc.source | Molecules, 2019, Vol. 24, No. 3, Article 422. | |
| dc.subject | carbenes | |
| dc.subject | cyclizations | |
| dc.subject | natural products | |
| dc.subject | polymers | |
| dc.subject | alkynes | |
| dc.subject | Chemistry and Biochemistry | |
| dc.title | Preparation and Utility of N-Alkynyl Azoles in Synthesis | |
| dc.type | Article |