Synergistic Effects of Monoculture Biofilm Dispersion and Antibiotic Treatment

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dc.contributor.advisorMcLean, Robert JC
dc.contributor.authorPowers, Shelbie
dc.contributor.committeeMemberKakirde, Kavita
dc.contributor.committeeMemberLewis, Karen A.
dc.date.accessioned2023-05-19T15:19:54Z
dc.date.available2023-05-19T15:19:54Z
dc.date.issued2021-05
dc.description.abstractBacterial biofilms have been identified as the causative agent of many infections, including catheter associated urinary tract infections (CAUTIs). While in a biofilm state, bacterial cells are less susceptible to antibiotic therapy. However, once released from a biofilm, antimicrobial susceptibility returns. In an aim to increase antibiotic efficacy of CAUTI treatment, uropathogenic Pseudomonas aeruginosa PAO1 and Escherichia coli F11 biofilms were cultured on silicone disks, modeling the surface of urinary catheters. These biofilms were then treated with two potential dispersal agents and challenged with antibiotics. Antibiotics selected were tobramycin and nitrofurantoin due to their clinical use against urinary tract infections. Both potential dispersal agents showed the most effect when used to treat P. aeruginosa biofilms cultured in Luria-Bertani broth (LB). There was no increased dispersal or improved antibiotic efficacy after treatment of modified artificial urine media (mAUM)-cultured P. aeruginosa biofilms.
dc.description.departmentBiology
dc.formatText
dc.format.extent63 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationPowers, S. (2021). Synergistic effects of monoculture biofilm dispersion and antibiotic treatment (Unpublished thesis). Texas State University, San Marcos, Texas.
dc.identifier.urihttps://hdl.handle.net/10877/16823
dc.language.isoen
dc.subjectBacterial biofilms
dc.subjectDispersion
dc.titleSynergistic Effects of Monoculture Biofilm Dispersion and Antibiotic Treatment
dc.typeThesis
thesis.degree.departmentBiology
thesis.degree.disciplineBiology
thesis.degree.grantorTexas State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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