Novel Topologically Complex Scaffold Derived from Alkaloid Haemanthamine

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dc.contributor.authorGovindaraju, Karthik
dc.contributor.authorMasi, Marco
dc.contributor.authorColin, Margaux
dc.contributor.authorMathieu, Veronique
dc.contributor.authorEvidente, Antonio
dc.contributor.authorHudnall, Todd W.
dc.contributor.authorKornienko, Alexander
dc.date.accessioned2019-08-30T13:56:37Z
dc.date.available2019-08-30T13:56:37Z
dc.date.issued2018-01
dc.description.abstractThe generation of natural product-like compound collections has become an important area of research due to low hit rates found with synthetic high-throughput libraries. One method of generating compounds occupying the areas of chemical space not accessible to synthetic planar heterocyclic structures is the utilization of natural products as starting materials. In the current work, using a ring-closing iodoalkoxylation reaction, alkaloid haemanthamine was transformed into a unique structural framework possessing an intricate ring system and a large number of stereocenters. The structure of the new compound was confirmed with an X-ray analysis. A small number of derivatives of this new compound were synthesized as a demonstration of the possibility of generating a large natural product-like compound collection based on the new structural framework.
dc.description.departmentChemistry and Biochemistry
dc.formatText
dc.format.extent8 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationGovindaraju, K., Masi, M., Colin, M., Mathieu, V., Evidente, A., Hudnall, T. W., & Kornienko, A. (2018). Novel topologically complex scaffold derived from alkaloid haemanthamine. Molecules, 23(2): 255.
dc.identifier.doihttps://doi.org/10.3390/molecules23020255
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/10877/8573
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute
dc.rights.holder© 2018 The Author(s).
dc.rights.licenseThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.sourceMolecules, 2018, Vol. 23, No. 2, Article 255.
dc.subjectdiversity-oriented synthesis
dc.subjecthaemanthamine
dc.subjecthaemanthidine
dc.subjectiodoalkoxylation
dc.subjectbiological activity
dc.subjectnatural product-like
dc.subjectChemistry and Biochemistry
dc.titleNovel Topologically Complex Scaffold Derived from Alkaloid Haemanthamine
dc.typeArticle

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