Maternal Omega-3 Fatty Acid Intake During Neurodevelopment Does Not Affect Pup Behavior Related to Depression, Novelty, or Learning
| dc.contributor.author | Jackson, Corey S. | |
| dc.contributor.author | Barrett, Douglas W. | |
| dc.contributor.author | Shumake, Jason | |
| dc.contributor.author | Gonzales, Elisa | |
| dc.contributor.author | Gonzalez-Lima, F. | |
| dc.contributor.author | Lane, Michelle A. | |
| dc.date.accessioned | 2019-08-05T17:32:12Z | |
| dc.date.available | 2019-08-05T17:32:12Z | |
| dc.date.issued | 2018-01 | |
| dc.description.abstract | Objective: Previously, we showed that consumption of a diet supplemented with omega-3 polyunsaturated fatty acids (n-3FAs) for two rounds of gestation and lactation increased the ability of rat dams to cope with stress when compared to dams that ingested a diet lacking n-3FAs. The objective of this study was to determine if the diets of these dams affected the behavior of their pups later in life. To isolate the neurodevelopmental effects of n-3FAs, pups from the second gestation were weaned to a diet adequate in n-3FAs. Pup testing began at 8 weeks of age and consisted of the forced swim, open field, and hole board tests to examine depression-related behavior, reaction to novelty, and learning and memory, respectively. Results: Given the considerable difference in the n-3FA content of the maternal diet, we expected a large effect size, however with the exception of rearing duration, maternal diet did not affect behavior in any of the tests conducted. These results suggest that maternal n-3FA supplementation during neurodevelopment likely does not affect offspring behavior when a diet adequate in n-3FA is provided post-weaning. Rather, we hypothesize that brain n-3FAs at the time of testing confer altered behavior and corroborate the need for additional research. | |
| dc.description.department | Family and Consumer Sciences | |
| dc.format | Text | |
| dc.format.extent | 7 pages | |
| dc.format.medium | 1 file (.pdf) | |
| dc.identifier.citation | Jackson, C., Barrett, D. W., Shumake, J., Gonzales, E., Gonzalez-Lima, F., Lane, M. A. (2018). Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning. BMC Research Notes, 11 : 812. | |
| dc.identifier.doi | https://doi.org/10.1186/s13104-018-3915-3 | |
| dc.identifier.uri | https://hdl.handle.net/10877/8455 | |
| dc.language.iso | en | |
| dc.publisher | BioMed Central | |
| dc.rights.holder | © 2018 The Authors. | |
| dc.rights.license | This work is licensed under a Creative Commons Attribution 4.0 International License. | |
| dc.source | BMC Research Notes, 2018, Vol. 11, Article 812 | |
| dc.subject | n-3 fatty acids | |
| dc.subject | depression | |
| dc.subject | novelty reactivity learning | |
| dc.subject | memory | |
| dc.subject | neurodevelopment | |
| dc.subject | Family and Consumer Sciences | |
| dc.title | Maternal Omega-3 Fatty Acid Intake During Neurodevelopment Does Not Affect Pup Behavior Related to Depression, Novelty, or Learning | |
| dc.type | Article |