Covalent Modification of Biological Targets with Natural Products through Paal-Knorr pyrrole Formation

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dc.contributor.authorKornienko, Alexander
dc.contributor.authorLa Clair, James
dc.date.accessioned2019-10-17T16:11:53Z
dc.date.available2019-10-17T16:11:53Z
dc.date.issued2017-08
dc.description.abstractNatural products and endogenous metabolites engage specific targets within tissues and cells through complex mechanisms. This review examines the extent to which natural systems have adopted the Paal-Knorr reaction to engage nucleophilic amine groups within biological targets. Current understanding of this mode of reactivity is limited by only a few examples of this reaction in a biological context. This highlight is intended to stimulate the scientific community to identify potential research directions and applications of the Paal-Knorr reaction in native and engineered biological systems.
dc.description.departmentChemistry and Biochemistry
dc.description.versionThis is the accepted manuscript version of an article published in Natural Product Reports.
dc.formatText
dc.format.extent34 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationKornienko, A., La Clair, J. (2017). Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation. Natural Product Reports, 34(9), pp. 1051–1060.
dc.identifier.doihttps://doi.org/10.1039/c7np00024c
dc.identifier.issn0265-0568
dc.identifier.urihttps://hdl.handle.net/10877/8677
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.sourceNatural Product Reports, 2017, Vol. 34, No. 9, pp. 1051–1060.
dc.subjectnatural products
dc.subjectendogenous metabolites
dc.subjectPaal-Knorr pyrrole formation
dc.subjectChemistry and Biochemistry
dc.titleCovalent Modification of Biological Targets with Natural Products through Paal-Knorr pyrrole Formation
dc.typeArticle

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