Characterization of Supra-Concentrate of Human Bone Marrow Stem Cells for the Treatment of Spine and Musculoskeletal Disorders

Simple item page
dc.contributor.authorPedrozo, Hugo
dc.contributor.authorDumitrescu, Mihnea
dc.date.accessioned2023-05-10T17:44:10Z
dc.date.available2023-05-10T17:44:10Z
dc.date.issued2023-04
dc.description.abstractThe use of autogenous stem cells is one of the pillars of regenerative medicine. The past one and a half decades have witnessed the discovery and characterization of a new type of adult stem cells named Very Small Embryonic-like stem (VSEL) cells. These cells exhibit pluripotency, they are localized in many tissues, including bone marrow and mobilized peripheral blood, which makes them easily accessible to the clinician. However, there are two major impediments to implementing their use in a clinical setting. First, current protocols that use blood or marrow as the source of therapeutic concentrates, such as platelet rich plasma (PRP) or bone marrow concentrate (BMAC), respectively, have not been characterized in terms of human VSEL (hVSEL) cell content. And second, there are no protocols to produce a concentrate of autologous hVSEL cells that can be implemented and in a clinical setting. STUDY OBJECTIVES 1. To characterize the current centrifugation method used in most clinics for nucleated cell concentration in terms of hVSEL cells yield, and 2. To develop a method for the enrichment of hVSEL cells derived from human bone marrow that is amenable to full implementation in a clinical setting.
dc.description.departmentBiology
dc.formatImage
dc.format.extent1 page
dc.format.medium1 file (.pdf)
dc.identifier.citationPedrozo, H., & Dumitrescu, M. (2023). Characterization of supra-concentrate of human bone marrow stem cells for the treatment of spine and musculoskeletal disorders. Poster presented at the Health Scholar Showcase, Translational Health Research Center, San Marcos, Texas.
dc.identifier.urihttps://hdl.handle.net/10877/16761
dc.language.isoen
dc.sourceHealth Scholar Showcase, 2023, Texas State University Translational Health Science Center, San Marcos, Texas, United States.
dc.subjectregenerative medicine
dc.subjectVSEL
dc.subjecthVSEL
dc.subjecthMSC
dc.subjectstem cells
dc.subjectmultipotency
dc.subjectpluripotency
dc.titleCharacterization of Supra-Concentrate of Human Bone Marrow Stem Cells for the Treatment of Spine and Musculoskeletal Disorders
dc.typePoster

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Pedrozo-THRC-Health Scholar Showcase.pdf
Size:
3.83 MB
Format:
Adobe Portable Document Format
Description:
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.54 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Health Scholar Showcase