Expression Signatures of Early-stage and Advanced Medaka Melanomas

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dc.contributor.authorKlotz, Barbara
dc.contributor.authorKneitz, Susanne
dc.contributor.authorRegensburger, Martina
dc.contributor.authorHahn, Lena
dc.contributor.authorDannemann, Michael
dc.contributor.authorKelso, Janet
dc.contributor.authorNickel, Birgit
dc.contributor.authorLu, Yuan
dc.contributor.authorBoswell, William T.
dc.contributor.authorPostlethwait, John
dc.contributor.authorWarren, Wesley C.
dc.contributor.authorKunz, Manfred
dc.contributor.authorWalter, Ronald B.
dc.contributor.authorSchartl, Manfred
dc.date.accessioned2019-09-04T19:01:58Z
dc.date.available2019-09-04T19:01:58Z
dc.date.issued2018-06
dc.description.abstractMelanoma is one of the most aggressive tumors with a very low survival rate once metastasized. The incidence of newly detected cases increases every year suggesting the necessity of development and application of innovative treatment strategies. Human melanoma develops from melanocytes localized in the epidermis of the skin to malignant tumors because of deregulated effectors influencing several molecular pathways. Despite many advances in describing the molecular changes accompanying melanoma formation, many critical and clinically relevant molecular features of the transformed pigment cells and the underlying mechanisms are largely unknown. To contribute to a better understanding of the molecular processes of melanoma formation, we use a transgenic medaka melanoma model that is well suited for the investigation of melanoma tumor development because fish and human melanocytes are both localized in the epidermis. The purpose of our study was to gain insights into melanoma development from the first steps of tumor formation up to melanoma progression and to identify gene expression patterns that will be useful for monitoring treatment effects in drug screening approaches. Comparing transcriptomes from juvenile fish at the tumor initiating stage with nevi and advanced melanoma of adults, we identified stage specific expression signatures and pathways that are characteristic for the development of medaka melanoma, and are also found in human malignancies.
dc.description.departmentChemistry and Biochemistry
dc.description.versionThis is the accepted manuscript version of an article published in Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology.
dc.formatText
dc.format.extent20 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationKlotz, B., Kneitz, S., Regensburger, M., Hahn, L., Dannemann, M., Kelso, J., Nickel, B., Lu, Y., Boswell, W., Postlethwait, J., Warren, W., Kunz, M., Walter, R. B., & Schartl, M. (2018). Expression signatures of early-stage and advanced medaka melanomas. Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 208, pp. 20–28.
dc.identifier.doihttps://doi.org/10.1016/j.cbpc.2017.11.005
dc.identifier.urihttps://hdl.handle.net/10877/8593
dc.language.isoen
dc.publisherElsevier
dc.sourceComparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 2018, Vol. 208, pp. 20–28.
dc.subjectmedaka
dc.subjectmelanoma
dc.subjectRNA-sequencing
dc.subjecttranscriptome
dc.subjecttransgenic fish model
dc.subjectgene expression signature
dc.subjectChemistry and Biochemistry
dc.titleExpression Signatures of Early-stage and Advanced Medaka Melanomas
dc.typeArticle

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