Adiponectin Influences FGF2 in the Developing Porcine Corpus Luteum

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dc.contributor.authorFlores, Rita
dc.contributor.authorRamirez, Martha
dc.contributor.authorAyala, Luis
dc.contributor.authorBenavides, Elizabeth
dc.contributor.authorXie, Fang
dc.contributor.authorArellano, Adrian
dc.contributor.authorStanko, Randy
dc.contributor.authorGarcia, Michelle
dc.date.accessioned2022-11-21T19:38:34Z
dc.date.available2022-11-21T19:38:34Z
dc.date.issued2022-02-12
dc.description.abstractLuteal angiogenesis is regulated by pro-angiogenic hormones including fibroblast growth factor 2 (FGF2) and angiopoietin 1 (Ang1), which are regulated by the adipokine leptin during development. Another adipokine, adiponectin, exhibits an inverse relationship with leptin and has been identified in the CL. Therefore, it is hypothesized that adiponectin will influence pro-angiogenic hormones in the developing porcine CL. Crossbred sows were randomly allocated to one of two days of the estrous cycle, day 5 (D5; n = 4) or day 7 (D7; n = 5) for CL collection. Tissue was processed for immunohistochemical localization of adiponectin receptor 2 (AdipoR2), gene expression of FGF2, Ang1, leptin, AdipoR2, and cell culture for adiponectin treatment. The expression of AdipoR2 tended (p = 0.09) to be higher in D7 lutea and was more prevalently localized to the cell surface of large and small luteal cells than in D5 tissue. Adiponectin influenced (p ≤ 0.05) FGF2, leptin, and AdipoR2 gene expression relative to the dose and day (D5 or D7). Collectively, the evidence supports the supposition that adiponectin influences angiogenic factors in the developing CL.
dc.description.departmentAgricultural Sciences
dc.formatText
dc.format.extent13 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationFlores, R., Ramirez, M., Ayala, L., Benavides, E. A., Xie, F., Arellano, A. A., Stanko, R. L., & Garcia, M. R. (2022). Adiponectin influences FGF2 in the developing porcine corpus luteum. Veterinary Sciences, 9(2), 77.
dc.identifier.doihttps://doi.org/10.3390/vetsci9020077
dc.identifier.issn2306-7381
dc.identifier.urihttps://hdl.handle.net/10877/16330
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute
dc.rights.licenseThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.sourceVeterinary Sciences, 2022, Vol. 09, No. 02, Article 77, pp. 1-13.
dc.subjectadiponectin
dc.subjectFGF2
dc.subjectAdipoR2
dc.subjectCL
dc.subjectporcine
dc.subjectAgricultural Sciences
dc.titleAdiponectin Influences FGF2 in the Developing Porcine Corpus Luteum
dc.typeArticle

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