Ozonated Autohemotherapy Modulates the Serum Levels of Inflammatory Cytokines in Gouty Patients
| dc.contributor.author | Li, Lian-Yun | |
| dc.contributor.author | Ma, Ruo-Lan | |
| dc.contributor.author | Du, Liqin | |
| dc.contributor.author | Wu, An-Shi | |
| dc.date.accessioned | 2019-10-17T15:24:57Z | |
| dc.date.available | 2019-10-17T15:24:57Z | |
| dc.date.issued | 2017-08 | |
| dc.description.abstract | Objectives: Ozonated autohemotherapy (O3-AHT) has been used to effectively treat gout, but the underlying therapeutic mechanisms remain unknown. In this study, as an initial effort to understand the therapeutic mechanisms of O3-AHT, we aim to examine the effect of O3-AHT on serum inflammatory cytokine levels in gouty patients. Patients and Methods: Three groups of patients and healthy subjects were recruited, including the gouty (n=10), hyperuricemia (n=10), and healthy control (n=11) groups. Cytometric bead array was applied to examine 12 cytokines before (T0), during (T1), and after (T2) therapies. Results: Three cytokines, IL-8, IL-12, and MCP-1, were detectable in all participants. Before O3-AHT, the average serum levels of IL-8 and MCP-1 were higher in the gout group than in the hyperuricemia and healthy control groups, confirming the inflammation status in gouty patients. After the 5th course of O3-AHT (T1), IL-8 level was significantly increased compared to that at T0. IL-12 level was also raised at T1, although the difference did not reach statistical significance. After completing the therapy, both IL-8 and IL-12 levels decreased to levels lower than those at T0. MCP-1 level remained essentially unchanged during and after treatment. Conclusion: Our results indicate that O3-AHT induces a significant change in serum cytokine levels, suggesting that modulating the inflammatory process is one of the therapeutic mechanisms underlying O3-AHT. In addition, the sensitive response of serum IL-8 and IL-12 levels to O3-AHT suggests that these cytokines may be developed as biomarkers to evaluate the therapeutic effect of O3-AHT in gouty patients. | |
| dc.description.department | Chemistry and Biochemistry | |
| dc.format | Text | |
| dc.format.extent | 7 pages | |
| dc.format.medium | 1 file (.pdf) | |
| dc.identifier.citation | Li, L., Ma, R., Du, L., & Wu, A. (2017). Ozonated autohemotherapy modulates the serum levels of inflammatory cytokines in gouty patients. Open Access Rheumatology: Research and Reviews, 9, pp. 159-165. | |
| dc.identifier.doi | https://doi.org/10.2147/OARRR.S119749 | |
| dc.identifier.issn | 1179-156X | |
| dc.identifier.uri | https://hdl.handle.net/10877/8676 | |
| dc.language.iso | en | |
| dc.publisher | Dove Medical Press | |
| dc.rights.holder | © 2017 Li et al. | |
| dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. | |
| dc.source | Open Access Rheumatology: Research and Reviews, 2017, Vol. 9, pp. 159-165. | |
| dc.subject | ozonated autohemotherapy | |
| dc.subject | inflammation | |
| dc.subject | cytokine | |
| dc.subject | gout | |
| dc.subject | Chemistry and Biochemistry | |
| dc.title | Ozonated Autohemotherapy Modulates the Serum Levels of Inflammatory Cytokines in Gouty Patients | |
| dc.type | Article |