Characterization of Beta Amyloid Formation and Its Effect on Alzheimer's Disease

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dc.contributor.advisorWhitten, Steven T.
dc.contributor.authorGates, Stephen Thomas
dc.date.accessioned2011-06-15T17:10:27Z
dc.date.available2012-02-24T10:09:57Z
dc.date.issued2011-05
dc.description.abstractAlzheimer’s disease (AD) is a neurodegenerative disease and terminal form of dementia that affects more than 27 million people worldwide. Among a large group of protein folding diseases, AD acts through the deposition and aggregation of β-amyloid (Aβ) within the brain’s blood vessels and outside senile plaques. The kinetics of Aβ42 was studied using thioflavin T fluorescence measurements to determine the formation of amyloid over time. Various purification techniques were compared in order to define the techniques necessary to effectively isolate monomeric Aβ42 before characterizing the formation of Aβ in vitro. The extreme conditions of ultracentrifugation were found to best isolate monomeric Aβ42. After further characterization of amyloidosis, future experimentation will utilize the screening of an oligopeptide library to identify sequences that bind to and possibly inhibit, promote, or dissolve formation of Aβ42 amyloid, which could lead to enhanced treatment of AD or the development of new drugs.
dc.description.departmentHonors College
dc.formatText
dc.format.extent34 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationGates, S. T. (2011). Characterization of beta amyloid formation and its effect on Alzheimer's Disease (Unpublished thesis). Texas State University-San Marcos, San Marcos, Texas.
dc.identifier.urihttps://hdl.handle.net/10877/3196
dc.language.isoen
dc.subjectAß42
dc.subjectAlzheimer
dc.subjectbeta amyloid
dc.subjectfluorescence
dc.subjectprotein folding disease
dc.subjectplaque
dc.subjectHonors College
dc.titleCharacterization of Beta Amyloid Formation and Its Effect on Alzheimer's Disease
thesis.degree.departmentHonors College
thesis.degree.disciplineChemistry and Biochemistry
thesis.degree.grantorTexas State University-San Marcos
txstate.documenttypeHonors Thesis

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