Deconvoluting Wavelengths Leading to Fluorescent Light Induced Infammation and Cellular Stress in Zebrafsh (Danio rerio)

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dc.contributor.authorBoswell, Mikki
dc.contributor.authorBoswell, William T.
dc.contributor.authorLu, Yuan
dc.contributor.authorSavage, Markita G.
dc.contributor.authorWalter, Ronald B.
dc.date.accessioned2020-03-11T17:56:32Z
dc.date.available2020-03-11T17:56:32Z
dc.date.issued2020-02
dc.description.abstractFluorescent light (FL) has been shown to induce a cellular immune and inflammatory response that is conserved over 450 MY of evolutionary divergence and among vertebrates having drastically different lifestyles such as Mus musculus, Danio rerio, Oryzias latipes and Xiphophorus maculatus. This surprising finding of an inflammation and immune response to FL not only holds for direct light receiving organs (skin) but is also observed within internal organs (brain and liver). Light responsive genetic circuitry initiated by the IL1B regulator induces a highly conserved acute phase response in each organ assessed for all of biological models surveyed to date; however, the specific light wavelengths triggering this response have yet to be determined so investigation of mechanisms and/or light specific molecule(s) leading to this response are difficult to assess. To understand how specific light wavelengths are received in both external and internal organs, zebrafish were exposed to specific 50 nm light wavebands spanning the visible spectrum from 300-600 nm and the genetic responses to each waveband exposure were assessed. Surprisingly, the induced cellular stress response previously observed following FL exposure is not triggered by the lower "damaging" wavelengths of light (UVB and UVA from 300-400 nm) but instead is maximally induced by higher wavelengths ranging from 450-500 nm in skin to 500-600 nm in both brain and liver).
dc.description.departmentChemistry and Biochemistry
dc.formatText
dc.format.extent14 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationBoswell, M., Boswell, W., Lu, Y., Savage, M., & Walter, R. B. (2020). Deconvoluting wavelengths leading to fluorescent light induced inflammation and cellular stress in zebrafish (Danio rerio). Scientific Reports, 10, 3321.
dc.identifier.doihttps://doi.org/10.1038/s41598-020-59502-5
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10877/9381
dc.language.isoen
dc.publisherNature Research
dc.rights.holder© 2020 The Author(s).
dc.rights.licenseThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.sourceScientific Reports, 2020, Vol. 10, Article 3321.
dc.subjectfluorescent light
dc.subjectinduced inflammation
dc.subjectcellular stress
dc.subjectzebrafish
dc.subjectDanio rerio
dc.subjectChemistry and Biochemistry
dc.titleDeconvoluting Wavelengths Leading to Fluorescent Light Induced Infammation and Cellular Stress in Zebrafsh (Danio rerio)
dc.typeArticle

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