Biodegradable Enzymatically Activated Nanoprobes for Dual Imaging and Therapy of Breast Cancer

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dc.contributor.advisorBetancourt, Tania
dc.contributor.authorYildiz, Tugba
dc.contributor.committeeMemberBeall, Gary W.
dc.contributor.committeeMemberCook, Jason
dc.contributor.committeeMemberIrvin, Jennifer A.
dc.contributor.committeeMemberWeigum, Shannon E.
dc.date.accessioned2018-09-19T15:18:18Z
dc.date.available2018-09-19T15:18:18Z
dc.date.issued2017-08
dc.description.abstract<p>Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of cancer deaths in women worldwide. Near infrared optical imaging has emerged recently as a viable alternative for the detection, monitoring, and image-guided therapy of tumors. Enzymatically activated nanoprobes utilize protease-labile polypeptides labeled with near infrared fluorophores as a mean to provide an off-to-on switch for fluorescence development that is triggered by tumor-overexpressed enzymes. Clinical use of doxorubicin is restricted by dose-dependent toxicity, multidrug resistance, and low specificity against cancer cells. Theranostic nanoprobes integrate diagnostic and therapeutic functions within an all-in-one platform.</p> <p>In this work, theranostic nanoprobes were synthesized with commonly used biocompatible and biodegradable polymers, and was used as cancer contrast and therapeutic agents for optical imaging and treatment of breast cancer. These core-shell structure nanoprobes were prepared with blends of biodegradable and biocompatible amphiphilic copolymers, poly(lactic-co-glycolic acid)-b-poly(ʟ-lysine), and poly(lactic acid)-b-poly(ethylene glycol). The protease cleavable polypeptide, poly(ʟ-lysine), was decorated with the near infrared fluorescent molecule AlexaFluor-750 for optical imaging of breast cancer cells. The chemotherapeutic drug doxorubicin was loaded into the core of nanoprobes for drug delivery.</p>
dc.description.departmentMaterials Science, Engineering, and Commercialization
dc.formatText
dc.format.extent140 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationYildiz, T. (2017). <i>Biodegradable enzymatically activated nanoprobes for dual imaging and therapy of breast cancer</i> (Unpublished dissertation). Texas State University, San Marcos, Texas.
dc.identifier.urihttps://hdl.handle.net/10877/7723
dc.language.isoen
dc.subjectBreast cancer
dc.subjectPolymer
dc.subjectBiodegradable
dc.subjectNanoprobes
dc.subjectImaging
dc.subjectTreatment
dc.subjectEnzymatic activation
dc.subjectBiocompatible
dc.subjectNIR imaging
dc.subjectChemotherapy
dc.subjectNanoparticles
dc.subjectCancer treatment
dc.subjectCancer imaging
dc.subjectAmphiphilic copolymers
dc.subject.lcshBreast--Canceren_US
dc.subject.lcshNanostructured materialsen_US
dc.subject.lcshCancer--Treatmenten_US
dc.titleBiodegradable Enzymatically Activated Nanoprobes for Dual Imaging and Therapy of Breast Cancer
dc.typeDissertation
thesis.degree.departmentMaterials Science, Engineering, and Commercialization Program
thesis.degree.disciplineMaterials Science, Engineering, and Commercialization
thesis.degree.grantorTexas State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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