Muscarinic Receptor Subtypes Involved in Pigment Granule Dispersion in Retinal Pigment Epithelium

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dc.contributor.advisorGarcia, Dana M.
dc.contributor.authorCopeland, Chad Michael
dc.date.accessioned2020-04-17T15:24:42Z
dc.date.available2020-04-17T15:24:42Z
dc.date.issued2005-05
dc.description.abstractPrevious studies have shown muscarinic receptors are involved in light driven pigment dispersion in retinal pigment epithelia (RPE). Pharmacological agents can be used to test this hypothesis and by selective inhibition, elucidate the sub-class of the receptor involved, and the intracellular downstream signaling pathway. RPE was isolated from Lepomis macrochirus, commonly known as bluegill, and treated with various pharmacological agents, including muscarinic receptor antagonists and agents to block second messenger pathway targets. Telenzepine and p-FHHSiD, M1 and M3 receptor antagonists, respectively, blocked pigment granule dispersion induced by carbachol, while methoctramine, an M2 antagonist did not. U73122 and 2-APB, a phospholipase C inhibitor and IP3-receptor antagonist, respectively, were also able to block carbachol-induce dispersion. Therefore, I conclude that carbachol-induced pigment dispersion 1s mediated through Modd receptors. I also propose that Ca2+ could be necessary for pigment dispersion induced by carbachol.
dc.description.departmentBiology
dc.formatText
dc.format.extent71 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationCopeland, C. M. (2005). Muscarinic receptor subtypes involved in pigment granule dispersion in retinal pigment epithelium (Unpublished thesis). Texas State University-San Marcos, San Marcos, Texas.
dc.identifier.urihttps://hdl.handle.net/10877/9639
dc.language.isoen
dc.subjectmuscarinic receptors
dc.subjectrhodopsin
dc.subjectepithelium
dc.subjectdispersion
dc.titleMuscarinic Receptor Subtypes Involved in Pigment Granule Dispersion in Retinal Pigment Epithelium
dc.typeThesis
thesis.degree.departmentBiology
thesis.degree.grantorTexas State University-San Marcos
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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