Moderate Physical Activity Mediates the Association between White Matter Lesion Volume and Memory Recall in Breast Cancer Survivors

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dc.contributor.authorCooke, Gillian E.
dc.contributor.authorWetter, Nathan
dc.contributor.authorBanducci, Sarah E.
dc.contributor.authorMackenzie, Michael J.
dc.contributor.authorZuniga, Krystle E.
dc.contributor.authorAwick, Elizabeth A.
dc.contributor.authorRoberts, Sarah A.
dc.contributor.authorSutton, Brad P.
dc.contributor.authorMcAuley, Edward
dc.contributor.authorKramer, Arthur
dc.date.accessioned2020-03-25T14:15:02Z
dc.date.available2020-03-25T14:15:02Z
dc.date.issued2016-02
dc.description.abstractIncreased survival rates among breast cancer patients have drawn significant attention to consequences of both the presence of cancer, and the subsequent treatment-related impact on the brain. The incidence of breast cancer and the effects of treatment often result in alterations in the microstructure of white matter and impaired cognitive functioning. However, physical activity is proving to be a successful modifiable lifestyle factor in many studies that could prove beneficial to breast cancer survivors. This study investigates the link between white matter lesion volume, moderate physical activity, and cognition in breast cancer survivors following treatment compared to non-cancer age-matched controls. Results revealed that brain structure significantly predicted cognitive function via mediation of physical activity in breast cancer survivors. Overall, the study provided preliminary evidence suggesting moderate physical activity may help reduce the treatment related risks associated with breast cancer, including changes to WM integrity and cognitive impairment.
dc.description.departmentFamily and Consumer Sciences
dc.formatText
dc.format.extent15 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationCooke, G. E., Wetter, N. C., Banducci, S. E., Mackenzie, M. J., Zuniga, K. E., Awick, E. A., Roberts, S. A., Sutton, B. P., McAuley, E., & Kramer, A. F. (2016) Moderate physical activity mediates the association between white matter lesion volume and memory recall in breast cancer survivors. PLoS ONE, 11(2): e0149552.
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0149552
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10877/9506
dc.language.isoen
dc.publisherPublic Library of Science
dc.rights.holder© 2016 Cooke et al.
dc.rights.licenseThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.sourcePLoS ONE, 2016, Vol. 11, No. 2, Article e0149552.
dc.subjectphysical activity
dc.subjectbreast cancer
dc.subjectmemory recall
dc.subjectwhite matter
dc.subjectlesion volume
dc.subjectFamily and Consumer Sciences
dc.titleModerate Physical Activity Mediates the Association between White Matter Lesion Volume and Memory Recall in Breast Cancer Survivors
dc.typeArticle

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