Working Towards a Cancer Cell Selective and Brain Penetrating Anti Glioma Drug

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dc.contributor.advisorKornienko, Alexander
dc.contributor.authorMiddleton, Kelsey
dc.contributor.committeeMemberHudnall, Todd
dc.contributor.committeeMemberLewis, Karen
dc.date.accessioned2016-11-07T21:44:45Z
dc.date.available2016-11-07T21:44:45Z
dc.date.issued2016-08
dc.description.abstractGlioblastoma multiforme is one of the most fatal and hardest to treat cancers. The main reasons for our failure to treat this type of cancer are the resistance to glioblastoma cells, to their high metastatic potential and poor drug penetration across the blood brain barrier. In previous research we have found that two alkaloids, lycorine and narciclasine, are effective in overcoming cancer cell resistance to apoptosis and potently inhibit glioblastoma cell growth and migration. In current research, described in this thesis, we attempted to take advantage of substrate active transport of lycorine and narciclasine into cancer cells as well as across the blood brain barrier using the GLUT1 transporter. To this end, we attempted to make various conjugates, of lycorine and narciclasine to glucose with the hypothesis that the glucose moiety would be recognized by GLUT1 and facilitate uptake of these molecules into brain cancer cells. Two such conjugates were successfully prepared and tested in cancer cells; however, it was found that these compounds were less potent than their parent alkaloids, suggesting that they were not good GLUT1 substrates.
dc.description.departmentChemistry and Biochemistry
dc.formatText
dc.format.extent109 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationMiddleton, K. (2016). <i>Working towards a cancer cell selective and brain penetrating anti glioma drug</i> (Unpublished thesis). Texas State University, San Marcos, Texas.
dc.identifier.urihttps://hdl.handle.net/10877/6340
dc.language.isoen
dc.subjectChemistry
dc.subjectBiochemistry
dc.subjectDrug design
dc.subjectMiddleton
dc.subjectKornienko
dc.subject.lcshCancer--Researchen_US
dc.subject.lcshDrugs--Designen_US
dc.subject.lcshBiochemistryen_US
dc.titleWorking Towards a Cancer Cell Selective and Brain Penetrating Anti Glioma Drug
dc.typeThesis
thesis.degree.departmentChemistry and Biochemistry
thesis.degree.disciplineChemistry
thesis.degree.grantorTexas State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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