High Throughput Preparation of Poly(Lactic-Co-Glycolic Acid) Nanoparticles Using Fiber Fluidic Reactor

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dc.contributor.authorAghda, Niloofar Heshmati
dc.contributor.authorLara, Emilio
dc.contributor.authorPatel, Pulinkumar
dc.contributor.authorBetancourt, Tania
dc.date.accessioned2021-07-27T18:46:01Z
dc.date.available2021-07-27T18:46:01Z
dc.date.issued2020-07-09
dc.description.abstractPolymeric nanoparticles (NPs) have a variety of biomedical, biotechnology, agricultural and environmental applications. As such, a great need has risen for the fabrication of these NPs in large scales. In this study, we used a high throughput fiber reactor for the preparation of poly(lactic-co-glycolic acid) (PLGA) NPs via nanoprecipitation. The fiber reactor provided a high surface area for the controlled interaction of an organic phase containing the PLGA solution with an aqueous phase, containing poly(vinyl alcohol) (PVA) as a stabilizer. This interaction led to the self-assembly of the polymer into the form of NPs. We studied operational parameters to identify the factors that have the greatest influence on the properties of the resulting PLGA NPs. We found that the concentration of the PLGA solution is the factor that has the greatest effect on NP size, polydispersity index (PDI), and production rate. Increasing PLGA concentration increased NP sizes significantly, while at the same time decreasing the PDI value. The second factor that was found to affect NP properties was the concentration of PVA solution, which resulted in increased NP sizes and decreased production rates. Flowrates of the feed streams also affected NP size to a lesser extent, while changing the operational temperature did not change the product’s features. In general, the results demonstrate that fiber reactors are a suitable method for the large-scale, continuous preparation of polymeric NPs suitable for biomedical applications.
dc.description.departmentChemistry and Biochemistry
dc.description.departmentMaterials Science, Engineering, and Commercialization
dc.formatText
dc.format.extent12 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationAghda, N. H., Lara, E. J., Patel, P., & Betancourt, T. (2020). High throughput preparation of poly(lactic-co-glycolic acid) nanoparticles using fiber fluidic reactor. Materials, 13(14), 3075.
dc.identifier.doihttps://doi.org/10.3390/ma13143075
dc.identifier.issn1996-1944
dc.identifier.urihttps://hdl.handle.net/10877/14102
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute
dc.rights.holder© 2020 The Authors.
dc.rights.licenseThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.sourceMaterials, 2020, Vol. 13, No. 14, Article 3075.
dc.subjectnanoprecipitation
dc.subjectnanoparticles
dc.subjectpolymers
dc.subjectpoly(lactic-co-glycolic acid) (PLGA)
dc.subjectprocess optimization
dc.subjectfiber reactor
dc.subjectlarge scale
dc.subjecthigh throughput preparation
dc.subjectChemistry and Biochemistry
dc.titleHigh Throughput Preparation of Poly(Lactic-Co-Glycolic Acid) Nanoparticles Using Fiber Fluidic Reactor
dc.typeArticle

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