Using Knot Theory to Model and Analyze DNA Replication and Recombination

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dc.contributor.advisorSnyder, David
dc.contributor.authorFarrell, Megan K.
dc.contributor.committeeMemberCurtin, Eugene
dc.contributor.committeeMemberDochtermann, Anton
dc.date.accessioned2018-11-14T16:07:53Z
dc.date.available2018-11-14T16:07:53Z
dc.date.issued2018-11
dc.description.abstractDue to DNA supercoiling inside the nucleus of a cell, DNA can be modeled as a mathematical knot. We will analyze and examine the knots and links that arise after single or multiple rounds of DNA recombi- nation using the tangle model. We will also examine how the topology of a DNA strand is modified during DNA replication and which enzymes directly alter the topology of the strand. The goal is to better understand the mechanism of site-specific recombination and knotted DNA replication through mathematical models.
dc.description.departmentMathematics
dc.formatText
dc.format.extent53 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationFarrell, M. K. (2018). <i>Using knot theory to model and analyze DNA replication and recombination</i> (Unpublished thesis). Texas State University, San Marcos, Texas.
dc.identifier.urihttps://hdl.handle.net/10877/7783
dc.language.isoen
dc.subjectKnot Theory
dc.subjectTopology
dc.subjectDNA
dc.subjectMath modeling
dc.subjectTangle model
dc.subjectTangles
dc.subject.lcshKnot theoryen_US
dc.subject.lcshDNA replicationen_US
dc.titleUsing Knot Theory to Model and Analyze DNA Replication and Recombination
dc.typeThesis
thesis.degree.departmentMathematics
thesis.degree.disciplineMathematics
thesis.degree.grantorTexas State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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